Paul L. Modrich

Paul Lawrence Modrich (born June 13, 1946) is an American biochemist, James B. Duke Professor of Biochemistry at Duke University and Investigator at the Howard Hughes Medical Institute. He is known for his research on DNA mismatch repair. Modrich received the Nobel Prize in Chemistry 2015, jointly with Aziz Sancar and Tomas Lindahl.

Early life and education

Modrich was born on June 13, 1946, in Raton, New Mexico to Laurence Modrich and Margaret McTurk. He has a younger brother Dave. His father was a biology teacher and coach for basketball, football and tennis at Raton High School where he graduated in 1964. origin. His paternal grandfather, of Croatian descent, is probably from the small village of Modrići near Zadar, and grandmother of Montenegrin descent, both immigrated to the United States from coastal Croatia in the late 19th century. His maternal family is of mixed German and Scotch-Irish descent.

Modrich obtained a B.S. degree from the Massachusetts Institute of Technology in 1968 and subsequently a Ph.D. degree from Stanford University in 1973. He continued his research as a postdoc in the lab of Charles C. Richardson at Harvard Medical School for a year (1973–1974). They later searched for proteins associated with mismatch repair in humans.

1983: Pfizer Award in Enzyme Chemistry 1996: General Motors Charles S. Mott Prize in Cancer Research 1998: Robert J. and Claire Pasarow Foundation Medical Research Award for cancer research 2000 Feodor Lynen Medal 2005: American Cancer Society Medal of Honor 2015: Nobel Prize in Chemistry 2016: Arthur Kornberg and Paul Berg Lifetime Achievement Award in Biomedical Sciences

Modrich is a fellow of the American Academy of Arts and Sciences and a member of the National Academy of Medicine and the National Academy of Sciences.