Avram Hershko

Avram Hershko (, ; born December 31, 1937) is a Hungarian-born Israeli biochemist who received the Nobel Prize in Chemistry in 2004.

Biography He was born Herskó Ferenc in Karcag, Hungary, into a Jewish family, the son of Shoshana/Margit 'Manci' (née Wulc) and Moshe Hershko, both teachers. During the Second World War, his father was forced into labor service in the Hungarian army and then taken as a prisoner by the Soviet Army. For years, Avram's family didn't know anything about what had happened to his father. Avram, his mother and older brother Chaim/Laszlo 'Laci' were put in a ghetto in Szolnok. During the final days of the ghetto, most Jews were sent to be murdered in Auschwitz, but Avram and his family managed to board trains that took them to a concentration camp in Austria, where they were forced into labor until the end of the war. Avram and his mother and brother survived the war and returned to their home. His father returned as well, 4 years after they had last seen him.

Hershko and his family emigrated to Israel in 1950 and settled in Jerusalem. He received his MD in 1965 and his PhD in 1969 from the Hebrew University of Jerusalem-Hadassah Medical Center. He was a postdoctoral scholar at the University of California, San Francisco. He is currently a Distinguished Professor at the Rappaport Faculty of Medicine at the Technion in Haifa and a Distinguished Adjunct Professor at the New York University Grossman School of Medicine.

Along with Aaron Ciechanover and Irwin Rose, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. The ubiquitin-proteasome system has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as cancer, muscular and neurological diseases, and immune and inflammatory responses.

His contributions to science directly helped cure one of his long-time friends of cancer.

Honours and awards 1987 – Weizmann Prize for Sciences 1994 – Israel Prize in Biochemistry 1999 – Canada Gairdner International Award (with Alexander Varshavsky) 2000 – Albert Lasker Award for Basic Medical Research (with Aaron Ciechanover and Varshavsky) 2000 – Alfred P. Sloan Jr. Prize (with Varshavsky) 2000 – Member, Israel Academy of Sciences and Humanities 2001 – Louisa Gross Horwitz Prize from Columbia University (with Varshavsky) 2001 – Massry Prize from the Keck School of Medicine of USC, University of Southern California (with Varshavsky) 2001 – Wolf Prize in Medicine (with Varshavsky) for "the discovery of the ubiquitin system of intracellular protein degradation and the crucial functions of this system in cellular regulation." 2002 – The EMET Prize for Art, Science and Culture in the category of Life Sciences (with Ciechanover and Leo Sachs) 2002 – E.B. Wilson Medal (with Varshavsky) 2003 – Foreign Associate, National Academy of Sciences, USA 2004 – Nobel Prize in Chemistry for his discovery with Ciechanover and Irwin Rose, of ubiquitin-mediated protein degradation 2005 – Elected to the American Philosophical Society

Publications

Involvement with biotechnology Hershko serves on the Scientific Advisory Board of Oramed Pharmaceuticals.