Jenny P. Glusker

Jenny Pickworth Glusker (born 28 June 1931) is a British biochemist and crystallographer. Since 1956 she has worked at the Fox Chase Cancer Center, a National Cancer Research Institute in the United States. She was also an adjunct professor of biochemistry and biophysics at the University of Pennsylvania.

Biography Jenny Pickworth was born on 28 June 1931 in Birmingham, England, the eldest of three siblings. Her parents were both physicians. Her father Frederick Alfred Pickworth was a chemist who studied medicine and did neurology research in Birmingham. Her mother, Jane Wylie Stocks, was from Scotland, studied medicine in Glasgow, and worked in Dublin in the 1920s. Stocks later got a job in Birmingham, where she married Frederick Alfred Pickworth.

During her school years, Pickworth developed an early enthusiasm for chemistry, due largely to her chemistry teacher and her mother's textbooks. Her parents wanted her to study medicine. She agreed with her father that she would attend the Medical School of the University of Birmingham if she was rejected from Somerville College of the University of Oxford. She successfully completed her entrance exam in Oxford, receiving her bachelor's degree in chemistry in 1953 and later earning her doctorate under Dorothy Hodgkin.

At the ICR, Glusker initially examined the structure of small molecules of the citric acid cycle, in particular aconitase-catalyzed citrate, and its conformation as a ligand to iron atoms of the iron-sulfur cluster of aconitase, which led to a better understanding of the three-dimensional structure and mechanism of the enzymes (ferrous-wheel mechanism). Later her laboratory performed crystallographic analyses of anti-tumor agents and, amongst others, the structure and conformation of estramustine and acridine. They further tested carcinogens such as polycyclic aromatic hydrocarbons as well as the structure of the enzyme xylose isomerase. 2011: John Scott Medal (Philadelphia City Council) 2014: William Procter Prize for Scientific Achievement

Glusker is an Honorary Fellow of Somerville College.

Selected publications By Kenneth N. Trueblood: Crystal Structure Analysis:. A primer (1st edition 1972, 2nd edition 1985) 3rd Edition, Oxford University Press, Oxford / New York 2010. With Dan McLachlan (ed.): Crystallography in North America American Crystallographic Association, New York 1983. . With Mitchell Lewis, Miriam Rossi: Crystal Structure Analysis for Chemists and Biologists VCH, New York 1994. .