Stanley Plotkin

Stanley Alan Plotkin (born 12 May 1932 is the standard reference on the subject. , Vaccines is in its eighth edition. Plotkin is also an editor of Clinical and Vaccine Immunology, which is published by the American Society for Microbiology in Washington, D.C..

Early life and education Plotkin was born and raised in New York City, the son of Jewish parents, Lee and Joseph Plotkin, who emigrated from England. He attended The Bronx High School of Science in New York City. While attending Bronx Science, at the age of 15, he read a pair of books that greatly influenced his future education and career choices: Arrowsmith by Sinclair Lewis and Microbe Hunters by Paul de Kruif. Deciding to dedicate his life to being a physician and research scientist, Plotkin graduated from Bronx Science in 1948. He then earned his bachelor's degree from New York University in 1952 and went on to earn his MD at SUNY Downstate Medical Center in 1956. Plotkin received his GME from the School of Medicine, University of Pennsylvania in 1963.

Career The Wistar Institute of Anatomy and Biology During his time at Wistar, Plotkin worked on several vaccines; chief among them are vaccines for rubella, rabies, rotavirus, and cytomegalovirus (CMV). He developed a vaccine for rubella, based upon the RA 27/3 strain of the virus (also developed by Plotkin using WI-38, a fetal-derived human cell line), which was released to the public in 1969. The enabling technology was the WI-38 cell strain gifted to Plotkin by Leonard Hayflick also of the Wistar. WI-38 provide the key elements for the successful Rubella vaccine. The virus became attenuated when grown on WI-38; it was free of unwanted viruses and the vaccine proved to have minor side effects when compared with the HPV vaccine developed at the NIH. This WI-38 grown vaccine led to the eradication of the disease in the United States, according to the Centers for Disease Control and Prevention, in 2005.

Plotkin, working with Tadeusz Wiktor and Hilary Koprowski, produced a human vaccine for rabies during the 1960s and 1970s also on the WI-38 cell strain gifted to them by Leonard Hayflick. WI-38 provided to the rabies vaccine the same properties that it gave to the rubella vaccine. This rabies vaccine can be used as a preventive measure for people who have an increased risk of contracting rabies, as well as a treatment for those who have been exposed recently to the disease, preventing infection in nearly 100 percent of cases.

Other positions held 1956: Internship, Cleveland Metropolitan General Hospital 1965–1972: Associate physician, Children's Hospital of Philadelphia 1972–1990: Director of infectious diseases and senior physician, Children's Hospital of Philadelphia 1974–1991: Professor of pediatrics and microbiology, School of Medicine, University of Pennsylvania 2003: Professor emeritus, Wistar Institute 2006: Professor emeritus of virology, University of Pennsylvania 2006: Executive advisor, Sanofi Pasteur 2014: Senior advisor, Global Virus Network Associate chairman, department of pediatrics, University of Pennsylvania Member, Center for HIV/AIDS Vaccine Immunology Adjunct professor, Johns Hopkins Bloomberg School of Public Health Scientific advisor, Mymetics 2017: Scientific advisor (and co-founder) of the Coalition for Epidemic Preparedness Innovations (CEPI)

Awards 2002: Albert B. Sabin Gold Medal 2009: Maxwell Finland Award for Scientific Achievement

Personal life Plotkin and his wife, Susan, have two children, Michael and Alec. In 1957, Plotkin wanted to join the US Air Force so that he could learn to fly, but instead he went to work for the Epidemic Intelligence Service. He eventually realized his dream of learning to fly at the age of 74.

Selected publications