Ronald W. Davis

Scientific career After completing his PhD at Caltech and a postdoctoral fellowship at Harvard University working with Jim Watson, Davis joined the faculty of Stanford's department of biochemistry in 1972.

Davis developed the R-loop technique of electron microscopy for mapping coding RNAs which led to the discovery of RNA splicing. With Janet E. Mertz, Davis was the first to demonstrate the use of restriction endonucleases for joining DNA fragments. Davis collaborated in the development of the first DNA microarray for gene expression profiling with Patrick O. Brown, and the gene expression profile of the first complete eukaryotic genome (Saccharomyces cerevisiae). Davis, with David Botstein, Mark Skolnick, and Ray White developed the method for constructing a genetic linkage map using restriction fragment length polymorphisms that enabled and led to the Human Genome Project.

He and his colleagues submitted a proposal to NIH to map the human genome in 1979; that proposal was turned down as being too ambitious.

He has won recognition for his contributions to genetic research from many groups, as early as 1976 and as recently as 2015, from one of his alumni colleges and from the National Academy of Sciences. In 2015, he received the Precision Medicine World Conference Luminary Award for his development of “R-loop Technique of Electron Microscopy”. In 2013, he received the Warren Alpert Foundation Prize.

He received the Gruber Prize in Genetics in 2011, which noted among other achievements, two landmark papers, one in 1977 concerning genome editing and another in 1980 which "helped launch the field of genomics." In 2007, California Institute of Technology gave him its Distinguished Alumni Award. In 2005, Davis received the Dickson Prize in Medicine. In 2004, he received the Lifetime Achievement Award from the Genetics Society of America. The National Academy of Sciences (NAS) gave him the 1982 NAS Award in Molecular Biology. In 1976, he received the Eli Lilly Award in Microbiology and Immunology.

Open Medicine Foundation Dr. Davis is the director of the Scientific Advisory Board at the Open Medicine Foundation, a non-profit organization, whose goal is to fund and initiate research into chronic complex diseases. Presently the foundation is invested in The End ME/CFS Project, which aims to fast-track research for a cure for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

In April 2019, a notable result was reported; a test of blood without red cells (white cells in plasma), identified ME/CFS patients from healthy people with 100% accuracy in a small sample, 20 patients and 20 healthy people. The test used a biotechnological device designed by Davis and his team, which is called the "nanoneedle".

“The small device that Davis and his colleagues created was originally developed to detect changes in electrical signals when cancer cells were exposed to different treatments.”, as described in Stat News. Their son, Whitney Dafoe was born in 1983, followed by their daughter Ashley Davis. Finally, even ordinary visual input (faces moving, light, colour, motion) started to provoke the same physiologic crash that heavy exercise provokes in milder patients. When that happens every stimulus—voice, touch, light—feels like being hit with a stun-gun. Whitney Dafoe has reached that extreme; only his parents have learned the rituals (dimmed light, fixed position, no sudden movement) that keep his nervous system from going into free-fall. As his endurance decreased, Dafoe moved back home in May 2011. His mother cut her work as a clinical psychologist to five hours a week to spend full time on his daily care as he continued declining in function, while Davis continues his research career and helps with his son's daily care. Dafoe's need for treatment is the motivation for Davis to direct his medical and scientific research efforts toward this disease; he dropped all other projects in hand before his son became so ill.