Edward Jenner

Edward Jenner (17 May 1749 – 26 January 1823) was an English physician and scientist who pioneered the concept of vaccines and created the smallpox vaccine, the world's first vaccine. The terms vaccine and vaccination are derived from Variolae vaccinae ("pustules of the cow"), the term devised by Jenner to denote cowpox. He used it in 1798 in the title of his Inquiry into the Variolae vaccinae known as the Cow Pox, in which Jenner described the protective effect of cowpox against smallpox.

Jenner is often called "the father of immunology", In 1821, he was appointed physician to King George IV, and was also made mayor of Berkeley and justice of the peace. Jenner was a member of the Royal Society. In the field of zoology, he was among the first modern scholars to describe the brood parasitism of the cuckoo (Aristotle also noted this behaviour in his History of Animals). In 2002, Jenner was named in the BBC's list of the 100 Greatest Britons.

Early life Edward Jenner was born on 17 May 1749 During this time, Jenner was inoculated (by variolation) for smallpox, which had a lifelong effect upon his general health. William Osler records that Hunter gave Jenner William Harvey's advice, well known in medical circles (and characteristic of the Age of Enlightenment), "Don't think; try." thumb

Jenner became a master mason on 30 December 1802, in Lodge of Faith and Friendship #449. From 1812 to 1813 he served as worshipful master of Royal Berkeley Lodge of Faith and Friendship.

Zoology

Jenner described how the newly hatched cuckoo pushed its host's eggs and fledgling chicks out of the nest (contrary to existing belief that the adult cuckoo did it). Having observed this behaviour, Jenner demonstrated an anatomical adaptation for itthe baby cuckoo has a depression in its back, not present after 12 days of life, that enables it to cup eggs and other chicks. The adult does not remain long enough in the area to perform this task. Jenner's findings were published in Philosophical Transactions of the Royal Society in 1788.

"The singularity of its shape is well adapted to these purposes; for, different from other newly hatched birds, its back from the scapula downwards is very broad, with a considerable depression in the middle. This depression seems formed by nature for the design of giving a more secure lodgement to the egg of the Hedge-sparrow, or its young one, when the young Cuckoo is employed in removing either of them from the nest. When it is about twelve days old, this cavity is quite filled up, and then the back assumes the shape of nestling birds in general." Jenner's nephew assisted in the study.

Jenner's understanding of the cuckoo's behaviour was not entirely believed until the artist Jemima Blackburn, a keen observer of birdlife, saw a blind nestling pushing out a host's egg. Blackburn's description and illustration were enough to convince Charles Darwin to revise a later edition of On the Origin of Species.

Jenner's interest in zoology played a large role in his first experiment with inoculation. Not only did Jenner have a profound understanding of human anatomy due to his medical training, but he also understood animal biology and its role in human–animal trans-species boundaries in disease transmission. At the time, there was no way of knowing how important this connection would be to the history and discovery of vaccinations. This connection can be seen today; many present-day vaccinations include animal parts from cows, rabbits and chicken eggs, which can be attributed to the work of Jenner and his cowpox/smallpox vaccination.

Marriage and human medicine A lecturer's certificate of attendance given to Jenner. He attended many lectures on chemistry, medicine and physics.

Jenner married Catherine Kingscote in March 1788 (she died of tuberculosis in 1815). He might have met her while he and other fellows were experimenting with balloons. Jenner's trial balloon descended into Kingscote Park, Gloucestershire, owned by Catherine's father, Anthony Kingscote. They had three children together: Edward Robert (1789–1810), Catherine Fitzhardinge (1794–1833), and Robert Fitzhardinge (1797–1854), who was 11 months old when Edward Jenner inoculated him with his cowpox vaccine.

Jenner earned his MD from the University of St Andrews in 1792. He is credited with advancing the understanding of angina pectoris. In his correspondence with Heberden, Jenner wrote: "How much the heart must suffer from the coronary arteries not being able to perform their functions".

Invention of the vaccine

Inoculation was already a standard practice in Asian and African medicine, but involved serious risks, including the possibility that those inoculated would become contagious and spread the disease to others. In 1721, Lady Mary Wortley Montagu had imported variolation to Britain after having observed it in Constantinople. While Johnnie Notions had great success with his self-devised inoculation (and was reputed not to have lost a single patient), his method's practice was limited to the Shetland Islands. Robert Sutton's method had similar success in Suffolk. Voltaire wrote that at this time, 60% of the population caught smallpox and 20% of the population died from it. He also stated that the Circassians used the inoculation from time immemorial, and that the Turks may have borrowed the custom from them. In 1766, Daniel Bernoulli analyzed smallpox morbidity and mortality data to demonstrate the efficacy of inoculation.

By 1768, the English physician John Fewster had realised that prior infection with cowpox rendered a person immune to smallpox. In the years following 1770, at least five investigators in England and Germany (Sevel, Jensen, Jesty 1774, Rendell, Plett 1791) successfully tested a cowpox vaccine against smallpox in humans. successfully vaccinated with cowpox and presumably induced immunity in his wife and two children during the 1774 smallpox epidemic, though it was not until Jenner's work that the procedure became widely understood. Jenner may have been aware of Jesty's procedures and success. In 1780, Jacques Antoine Rabaut-Pommier made similar observations in France.

Jenner postulated that the pus in blisters from sufferers of cowpox (a disease similar to smallpox but much less virulent) protected them from smallpox. On 14 May 1796, he tested his hypothesis by inoculating James Phipps, the eight-year-old son of Jenner's gardener. Jenner scraped pus from cowpox blisters on the hands of Sarah Nelmes, a milkmaid who had caught cowpox from a cow called Blossom ). Phipps was the 17th case described in Jenner's first paper on vaccination.

Jenner inoculated Phipps through two small cuts on his arm that day; this led to a fever and some uneasiness, but no full-blown infection.

The American physician Donald Hopkins has written, "Jenner's unique contribution was not that he inoculated a few persons with cowpox, but that he then proved [by subsequent challenges] that they were immune to smallpox. Moreover, he demonstrated that the protective cowpox pus could be effectively inoculated from person to person, not just directly from cattle." Some of Jenner's conclusions were correct, some erroneous; modern microbiological and microscopic methods would make his studies easier to reproduce. The medical establishment deliberated at length over his findings before accepting them. Eventually, vaccination was accepted, and in 1840, the British government banned variolationthe use of smallpox to induce immunityand provided vaccination using cowpox free of charge (see Vaccination Act).

The success of Jenner's discovery soon spread around Europe and was used en masse in the Spanish Balmis Expedition (1803–1806), a three-year-long mission to the Americas, the Philippines, Macao and China led by Francisco Javier de Balmis with the aim of giving the smallpox vaccine to thousands. The expedition was successful, and Jenner wrote: "I don't imagine the annals of history furnish an example of philanthropy so noble, so extensive as this". Napoleon, who at the time was at war with Britain, had all his French troops vaccinated, awarded Jenner a medal, and at Jenner's request, released two English prisoners of war, allowing them to return home. Napoleon remarked he could not "refuse anything to one of the greatest benefactors of mankind".

Jenner's continuing work on vaccination prevented him from continuing his ordinary medical practice. He was supported by his colleagues and King George III in petitioning Parliament, and was granted £10,000 for his work on vaccination in 1802. and a foreign member of the Royal Swedish Academy of Sciences in 1806. In 1803, he became president of the Jennerian Society in London, concerned with promoting vaccination to eradicate smallpox. The Jennerian ceased operations in 1809. Jenner became a member of the Medical and Chirurgical Society on its founding in 1805 (now the Royal Society of Medicine) and presented several papers there. In 1808, with government aid, the National Vaccine Establishment was founded, but Jenner felt dishonoured by the men selected to run it and resigned his directorship.

Returning to London in 1811, Jenner observed a significant number of cases of smallpox after vaccination. He found that in these cases the severity of the illness was notably diminished by previous vaccination. In 1821, Jenner was appointed physician extraordinary to King George IV and was also made mayor of Berkeley

Jenner was a Freemason.

Death Jenner was found in a state of apoplexy on 25 January 1823, with his right side paralysed. Jenner did not recover and died the next day of an apparent stroke, his second, at age 73. Jenner was buried in the family vault at the Church of St Mary, Berkeley.

Religious views

Neither fanatic nor lax, Jenner was a Christian who in his personal correspondence showed himself quite spiritual. Some days before his death, Jenner stated to a friend: "I am not surprised that men are not grateful to me; but I wonder that they are not grateful to God for the good which He has made me the instrument of conveying to my fellow creatures".

Legacy In 1980, the World Health Organization declared smallpox an eradicated disease. This was the result of co-ordinated public health efforts, but vaccination was an essential component. Although the disease was declared eradicated, some pus samples still remain in laboratories in Centers for Disease Control and Prevention in Atlanta, United States, and in the State Research Center of Virology and Biotechnology VECTOR in Koltsovo, Novosibirsk Oblast, Russia.

Jenner's vaccine laid the foundation for contemporary discoveries in immunology. Commemorated on postage stamps issued by the Royal Mail, Jenner featured in their World Changers issue along with Charles Darwin, Michael Faraday and Alan Turing in 1999. The lunar crater Jenner is named in his honour.

POX, a play by Janet Bolam, was performed by the Cotswold Players in the garden of Jenner's House in 2025.

Monuments and buildings Jenner's house in the village of Berkeley, Gloucestershire, is now a small museum, Another statue of Jenner was erected in Trafalgar Square and later moved to Kensington Gardens. London's St George's Hospital Medical School has a Jenner Pavilion, where his bust may be found. Jennersville, Pennsylvania, US, is located in Chester County. The Edward Jenner Institute for Vaccine Research is an infectious disease vaccine research centre, also the Jenner Institute part of the University of Oxford. A section at Gloucestershire Royal Hospital is known as the Edward Jenner Unit; it is where blood is drawn. A ward at Northwick Park Hospital is called Jenner Ward. Jenner Gardens at Cheltenham, Gloucestershire, opposite one of his former offices, is a small garden and cemetery. A statue of Jenner was erected at the Tokyo National Museum in 1896 to commemorate the centenary of Jenner's discovery of vaccination. A monument outside the walls of the upper town of Boulogne sur Mer, France. A street in Stoke Newington, north London: Jenner Road, N16 Built around 1970, the Jenner Health Centre, 201 Stanstead Road, Forest Hill, London, SE23 1HU Jenner's name is featured on the Frieze of the London School of Hygiene & Tropical Medicine. Twenty-three names of public health and tropical medicine pioneers were chosen to feature on the Keppel Street building when it was constructed in 1926. The minor planet 5168 Jenner is named in his honour.

Publications 1798 An Inquiry Into the Causes and Effects of the Variolæ Vaccinæ 1799 Further Observations on the Variolæ Vaccinæ, or Cow-Pox 1800 A Continuation of Facts and Observations relative to the Variolæ Vaccinæ 40pp. 1801 The Origin of the Vaccine Inoculation