Wim Crusio

Wim E. Crusio (born Wilhelmus Elisabeth Crusio on 20 December 1954) is a Dutch behavioral neurogeneticist and a directeur de recherche (research director) with the French National Centre for Scientific Research in Talence, France.

Education and career Crusio received his bachelor's degree in biology from Radboud University Nijmegen in 1975, where he went on to obtain a master's degree and then a PhD in 1979 and 1984, respectively. His Anubias revision, which was originally published in 1979, and continues to engender interest. For his PhD thesis, Crusio studied the inheritance of the effects of anosmia on exploratory behavior of mice, and more in general the genetic architecture of exploratory behavior, using quantitative-genetic methods such as the diallel cross.

From 1984 to 1987, Crusio worked as a postdoc at the University of Heidelberg, supported by a NATO Science Fellowship and an Alexander von Humboldt Research Fellowship. During 1988, Crusio spent a year in Paris, France, supported by a fellowship from the Fyssen Foundation. He then returned to Heidelberg as a senior research scientist before being recruited as chargé de recherche by the CNRS, initially working in an institute of the Université René Descartes (Paris V) and later moving to the CNRS campus in Orléans, having been promoted to directeur de recherche. He is currently adjunct director of the Institut de Neurosciences Cognitives et Intégratives d'Aquitaine.

Research

Hippocampal mossy fibers

Crusio and his collaborators found that neuroanatomical variations in the mouse hippocampus, in particular the sizes of their intra- and infrapyramidal mossy fibers (IIPMF) correlated with learning performance. Together with Herbert Schwegler and Hans-Peter Lipp, Crusio showed that an inverse correlation, that is, animals with larger IIPMF learn better, could be found for spatial learning in a radial arm maze task. Taken together, Crusio and collaborators think that it is highly likely that this correlation is causal, although this is not universally accepted.

Mouse model of depression When mice are exposed to unpredictable chronic mild stress (UCMS), they start exhibiting symptoms reminiscent of major depressive disorder in humans. As it had been suggested that deficits in hippocampal neurogenesis might underlie depression, Crusio and collaborators undertook a series of experiments investigating changes in behavior and neurogenesis in mice that had undergone UCMS. They showed dramatic changes in levels of aggression, anxiety, depressive-like behaviors, with a concomitant drop in neurogenesis. A review of the findings obtained with these mice in many different laboratories did indeed indicate that these animals display autistic-like symptoms, especially changes in social behavior, a key symptom of autism.

Editorial activities Crusio is the founding editor-in-chief of Genes, Brain and Behavior, which he edited from 2001 to 2011. The standards for the publication of mouse mutant studies that he and his co-editors developed for this journal are gradually being accepted in the field. Since 2017, Crusio is the editor-in-chief of Behavioral and Brain Functions and since 2019 co-editor of Advances in Experimental Medicine and Biology. He is also an academic editor of PLoS ONE and served as associate editor of Behavioral and Brain Sciences (1991–2008) and The Scientific World Journal (2002-2011). Crusio serves or has served on the editorial boards of Behavioral and Brain Functions, Behavior Genetics (1991–1995), Behavioural Brain Research (1997–2007), BMC Neuroscience, BMC Research Notes, Frontiers in Behavioral Neuroscience, Journal of Visualized Experiments, Molecular Brain (2012-2017), Neurogenetics (1998–2006), Physiology and Behavior, and Current Opinion in Behavioral Sciences. He edited special issues for the journals Behavior Genetics, Behavioural Brain Research, Physiology and Behavior (with Robert Gerlai), Hippocampus (with Aryeh Routtenberg), and Brain Research Bulletin (with Catherine Belzung and Robert Gerlai). Together with Robert Gerlai he also edited a handbook on molecular genetic techniques for behavioral neuroscience. Currently, he is editing the Cambridge Handbooks in Behavioral Genetics, a series of handbooks published by Cambridge University Press, of which the first volume, Behavioral Genetics of the Mouse: Genetics of Behavioral Phenotypes, appeared in 2013. Since then, two more volumes have appeared.

Community service In 1996, Crusio was one of two co-founders of the International Behavioural and Neural Genetics Society, for which he served as member-at-large of the executive committee, treasurer, and president (1998–2001). In 2011 he received from this society the "Distinguished Service Award", which is given for exceptional contributions to the field of behavioral neurogenetics. Crusio also served on the executive committees of the Behavior Genetics Association (from which he resigned in protest to Glayde Whitney's 1995 presidential address), the European Brain and Behaviour Society, and the International Behavioral Neuroscience Society, and has been a President of the Dutch Behavior Genetics Contact Group. He has been a member of several program committees for scientific meetings, most notably the 8th and 10th World Congresses of Psychiatric Genetics and the 2008, 2009 (co-chair), 2010 (chair), and 2011 (chair) Annual Meetings of the IBNS.

Significant papers

According to Google Scholar, Crusio's works have been cited over 11,000 times and he has an h-index of 50. Some significant papers are:

Original publication: