William K. Oh

William K. Oh, is an American medical oncologist, academic leader and expert in the management of prostate cancer. He has also held leadership roles in industry and non-profits, including as current Chair of the American Cancer Society’s National Prostate Cancer Roundtable.

Oh is Director of Precision Medicine for Yale Cancer Center and Smilow Cancer Hospital. He is also Medical Director for the Cancer Service Line at Smilow Cancer Hospital in Greenwich. He previously served as Chief Medical Officer for the Prostate Cancer Foundation, the world’s leading philanthropy for prostate cancer. He was also CMO of Sema4 (now known as GeneDx), a publicly traded genomics and health intelligence company. For 11 years, Oh was Chief of the Division of Hematology and Medical Oncology at The Mount Sinai Medical Center in New York City, Deputy Director at Mount Sinai's NCI-designated Tisch Cancer Institute, Professor of Medicine and Urology and the Ezra M. Greenspan, M.D., Professor in Clinical Cancer Therapeutics at The Icahn School of Medicine at Mount Sinai.

Oh is the author of more than 400 publications. He is the editor of 6 books and the author of 25 book chapters. He has been repeatedly listed in Castle Connolly's "America's Top Doctors for Cancer", "Best Doctors in America”, and in New York Magazine's "Top Doctors" from 2010–2025. He has been named a Top AAPI doctor for 2023, 2024 and 2025.

Biography Oh earned a B.S. from Yale University in 1987 and his M.D. from New York University School of Medicine in 1992. He completed an internship and a residency at Brigham and Women's Hospital in Boston and a clinical fellowship at the Dana–Farber Cancer Institute.

From 1997 to 2009, Oh served on the faculty of Harvard Medical School, where he was Associate Professor of Medicine and Clinical Director of the Lank Center for Genitourinary Oncology. In 2009, he joined The Mount Sinai Medical Center as the Ezra M. Greenspan Professor in Clinical Cancer Therapeutics and Professor of Medicine and Urology, as well as Chief of the Division of Hematology and Medical Oncology in Mount Sinai's Department of Medicine. and for three trials of neoadjuvant chemotherapy in high-risk localized prostate cancer patients.

At the Dana–Farber Cancer Institute, from 2000 to 2009, Oh developed and managed a prospective clinical database linked to blood and tissue banks for more than 8,000 prostate cancer patients, with links to blood samples and tissue repositories, for exploration of research and prognostic applications, including: efficacy of various therapies in CRPC, hormonal therapy, testosterone as a marker for cancer outcome, relapse predictions based on nutritional factors at diagnosis and autoantibody signatures, and assessment of pharmacogenomic patterns predicting Gleason score. At Mount Sinai and Sema4, he continued his work in precision medicine by continuing to leverage clinicogenomic databases to understand cancer outcomes.

Oh served in leadership roles as CMO of Sema4/GeneDx, a health intelligence company spun out of Mount Sinai, as well the Prostate Cancer Foundation, a 30 year old philanthropy dedicated to discovering new treatments for advanced prostate cancer. At PCF, he led a panel and paper recommending Guidelines for PSA Screening of Black Men in the US, published in NEJM Evidence.

He recently returned to academic medicine at Yale School of Medicine as Professor of Medicine and Director of Precision Medicine for Yale Cancer Center and Smilow Cancer Hospital.

Honors and awards 1992 Alpha Omega Alpha 2003–present, Best Doctors in America 2005 2009 Boston Magazine "Top Doctors" 2007–2008 Brigham/Harvard Business School Physician Leadership Program 2008–present, America's Top Doctors for Cancer (Castle Connolly) 2010 Prostate Cancer Foundation Creativity Award 2010–present, New York Magazine "Top Doctors" 2011 Election to the American Society of Clinical Investigation (ASCI) 2013 Fellow, American College of Physicians (FACP) 2023, 2024, 2015 Castle Connolly Top AAPI Doctor 2010-2024, NY Super Doctors Hall of Fame 2025–present, Connecticut Magazine “Top Doctors”

Publications Partial list: