Ramanujan Shankar Hegde

thesis_title = The regulation of protein translocation at the endoplasmic reticulum thesis_url = https://www.proquest.com/docview/304415938/ thesis_year = 1998 doctoral_advisor = Vishwanath R. Lingappa is a group leader at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB). Since 2019 he has led the LMB's Cell Biology Division.

Education Hegde was educated at the University of Chicago

Research and career Hegde's research investigates how proteins are localised correctly inside cells, and how errors during protein maturation are recognised and disposed. These processes are important because the accumulation of abnormal proteins is disruptive to cell function, and underlies numerous diseases. needed by a subset of proteins to reach their correct membrane-embedded destination. Their studies of such protein targeting pathways are revealing how membrane proteins are accurately recognised by the machinery responsible for their proper localisation and insertion. Hegde's work has also shown that even modest failures of individual proteins to reach their correct cellular location can lead to neurodegeneration, and that cells have specialised pathways to identify these wayward proteins and target them for destruction. his most cited research include papers published in Science, Nature, and Cell.

Awards and honours Hegde was awarded the R.R. Bensley award in Cell Biology in 2008 and elected a member of the European Molecular Biology Organisation (EMBO) in 2013.