Paul Babitzke

Paul Babitzke is a professor of biochemistry and molecular biology and director of the Center for RNA Molecular Biology at Pennsylvania State University.

Education

Paul Babitzke obtained his B.A. in biomedical science from St. Cloud State University in Minnesota in 1994. He earned his Ph.D. in genetics from the University of Georgia in 1991.

Since 2009, he has been serving as director of the Center for RNA Molecular Biology in the Penn State Huck Institutes of the Life Sciences. His research focuses on the regulation of gene expression mediated by RNA polymerase pausing, transcription termination, RNA structure, and RNA-binding proteins.

In 2016, he was elected as Fellow of the American Association for the Advancement of Science. Fellow, American Academy of Microbiology (AAM) (2017) Yakhnin, A.V., and Babitzke, P. (2002) NusA-stimulated RNA polymerase pausing and termination participates in the Bacillus subtilis trp operon attenuation mechanism in vitro. Proc. Natl. Acad. Sci. USA. 99:11067-11072. Yakhnin, A.V., Yakhnin, H., and Babitzke, P. (2006) RNA polymerase pausing participates in the Bacillus subtilis trpE translation control mechanism by providing additional time for TRAP to bind to the nascent trp leader transcript. Mol. Cell 24:547-557. Yakhnin, A.V., Yakhnin, H., and Babitzke, P. (2008) Function of the Bacillus subtilis transcription elongation factor NusG in hairpin-dependent RNA polymerase pausing in the trp leader. Proc. Natl. Acad. Sci. USA 105:16131-16136. Yakhnin, H., Yakhnin, A.V., Baker, C.S., Sineva, E., Berezin, I., Romeo, T., and Babitzke, P. (2011) Complex regulation of the global regulatory gene csrA: CsrA-mediated translational repression, transcription from five promoters by Es70 and EsS, and indirect transcriptional activation by CsrA. Mol. Microbiol. 81:689-704. Yakhnin, A.V., Baker, C.S., Vakulskas, C.A., Yakhnin, H., Berezin, I., Romeo, T., and Babitzke, P. (2013) CsrA activates flhDC expression by protecting flhDC mRNA from RNase E-mediated cleavage. Mol. Microbiol. 87:851-866. Mondal, S., Yakhnin, A.V., Sebastian, A., Albert, I., and Babitzke, P. (2016) NusA-dependent transcription termination prevents misregulation of global gene expression. Nat. Microbiol. 1:15007. Potts, A.H., Vakulskas, C.A., Pannuri, A., Yakhnin, H., Babitzke, P., and Romeo, T. (2017) Global role of the bacterial post-transcriptional regulator CsrA revealed by integrated transcriptomics. Nat. Commun. 8:1596. Yakhnin, A.V., FitzGerald, P.C., McIntosh, C., Yakhnin, H., Kireeva, M., Turek-Herman, J., Mandell, Z.F., Kashlev, M., and Babitzke, P. (2020) NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome. Proc. Natl. Acad. Sci. USA 117:21628-21636. Mandell, Z.F., Oshiro, R.T., Yakhnin, A.V., Kashlev, M., Kearns, D.B., and Babitzke, P. (2021) NusG is an intrinsic transcription termination factor that stimulates motility and coordinates gene expression with NusA. eLife 10:e61880.