Margaret Tisdale

Margaret Tisdale (née Breeze; 10 September 1950 – 29 April 2015) was a Welsh-born clinical virologist known for her studies of antiviral resistance in HIV and influenza virus, and for coordinating the development of the anti-influenza drug zanamivir.

Biography Born in Welshpool, Tisdale was educated at Trefnanney School and Welshpool Comprehensive, before attending Guildford University.

She died aged 64 in Wrestlingworth, Bedfordshire.

Selected publications M Tisdale, SD Kemp, NR Parry, BA Larder (1993). Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase. Proceedings of the National Academy of Sciences of the United States of America 90: 5653–56 M Tisdale, T Alnadaf, D Cousens (1997). Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89. Antimicrobial Agents and Chemotherapy 41: 1094–98 M Tisdale (2000). Monitoring of viral susceptibility: new challenges with the development of influenza NA inhibitors. Reviews in Medical Virology 10: 45–55