Katrina T. Forest

Katrina T. Forest (born 1966) is an American biologist who is the EB Fred Professor of Bacteriology and Chair in the Department of Bacteriology at the University of Wisconsin–Madison. Her research considers the use of structural biology to better understand pathogenesis. Forest is a Fellow of the American Society for Microbiology.

Early life and education Forest was born in Honolulu. Her father was in the United States Navy, and she lived in Philadelphia, Baltimore and Madison during her childhood. She was encouraged to study science at university, and eventually completed her bachelor's degree at the Massachusetts Institute of Technology. Her mother became unwell whilst she was an undergraduate student, and Forest spent a semester closer to home at the University of Wisconsin–Madison. Forest was a postdoctoral researcher at Scripps Research where she specialized in protein crystallography. She was the first to realize the three-dimensional structures of a bacterial phytochrome, and predicted that the bacteriophytochrome architecture first arose around one billion years ago. The phytochrome tells plants when to germinate and when not to germinate, as well as identifying where plants should grow to absorb the most light possible. She derived the phytochrome from Deinococcus radiodurans, a species of bacterium that was known to be tolerant to ionising radiation.

Recognizing the impact of protein molecular structure on biological function, Forest turned to the design of novel proteins with tuneable properties. Amongst these, she identified a stable synthetic collagen that may offer hope for conditions such as arthritis. The modified protein contains less flexible amino acids to the original form, which stiffens the structure and helps the protein to maintain structural integrity even when exposed to elevated temperatures.

Forest worked with Laura L. Kiessling to investigate the protein Intelectin, demonstrating that it can identify different types of pathogens and distinguish pathogens from human cells. The pair showed that this protein is upregulated during infection, indicating that it might have some antimicrobial properties. 2003 University of Wisconsin–Madison CALS Pound Research Award 2015 Fellow of the Institut d'Etudes Avancées d'Aix-Marseille Université 2015 Fellow of the American Academy of Microbiology 2018 University of Wisconsin–Madison Vilas Associates Award 2023 Fellow of the American Association for the Advancement of Science

Selected publications

Personal life Forest lives with her husband in Madison, Wisconsin.