James Batcheller Sumner

James Batcheller Sumner (November 19, 1887 – August 12, 1955) was an American biochemist. He discovered that enzymes can be crystallized, for which he shared the Nobel Prize in Chemistry in 1946 with John Howard Northrop and Wendell Meredith Stanley. He was also the first to prove that enzymes are proteins.

Biography Sumner was born on November 19, 1887, in Canton, Massachusetts.

While hunting at age 17, Sumner was accidentally shot by a companion and as a result his left arm had to be amputated just below the elbow. He had been left-handed before the accident, after which he had to learn to do things with his right hand.

Sumner married Cid Ricketts (born Bertha Louise Ricketts in Brookhaven, Mississippi) when she attended medical school at Cornell. They married on July 10, 1915, and had four children. They were divorced in 1930, but she kept her married name. Cid Ricketts Sumner went on to become an author, writing books that included Tammy Tell Me True, which was made into the movie Tammy and the Bachelor, and Quality, which became the movie Pinky. Cid Ricketts Sumner was murdered by their grandson, John R. Cutler, in 1970.

In 1931 Sumner married Agnes Lundkvist. In 1943 they divorced; later that year he married Mary Beyer, with whom he had two children. This was the first experimental proof that an enzyme is a protein, a controversial question at the time.

His successful research brought him to full professorship at Cornell in 1929. From 1924 on his laboratory was located on the second floor of the new dairy science building, Stocking Hall (today home to Food Science), at Cornell where he did his Nobel Prize–winning research. In 1937 he succeeded in isolating and crystallizing a second enzyme, catalase. By this time, John Howard Northrop of the Rockefeller Institute had obtained other crystalline enzymes by similar methods, starting with pepsin in 1929. It had become clear that Sumner had devised a general crystallization method for enzymes, and also that all enzymes are proteins.

Honors and awards In 1937, he was given a Guggenheim Fellowship and he spent five months in Sweden working with Professor Theodor Svedberg. Also that year, he was awarded the Scheele Award in Stockholm.

Both Sumner and Northrop, along with Wendell M Stanley, shared the Nobel Prize in 1946 for crystallization of enzymes.

Death Sumner died at age 67 of cancer in Buffalo, New York on August 12, 1955.