Henri Laborit

Henri Laborit (21 November 1914 – 18 May 1995) was a French surgeon, neurobiologist, writer and philosopher. In 1952, Laborit was instrumental in the development of the drug chlorpromazine, published his findings, and convinced three psychiatrists to test it on a patient, resulting in great success. Laborit was recognized for his work, but as a surgeon searching for an anesthetic, he came to be at odds with psychiatrists who made their own discoveries and competing claims.

Laborit wrote several books where he popularizes his ethological laboratory research and marries it, through systems thinking, with knowledge from several other disciplines, being a strong advocate of interdisciplinarity and transdisciplinarity. His writings can also be found to have deep roots in anarchist thought. He was personally untroubled by the requirements of science and the constraints of university life. He maintained an independence from academia and never sought to produce the orderly results that science requires of its adherents. During World War II he was stationed on the torpedo boat Sirocco, where he witnessed the evacuation of the Dunkerque, and then was sunk by the Germans. He was saved by an English sloop that picked him up. He received the French Military Cross with distinction. He was later stationed in Dakar. By about 1949 he was appointed to Val-de-Grâce hospital in Paris. In his years in Bizerte he became interested in the use of the antihistamine promethazine to make patients more relaxed before surgery and in contributing to anesthesia, observations that were the forerunner of his later interest in chlorpromazine.

With Pierre Huguenard, Laborit invented the lytic cocktail, a combination of drugs that could be given to patients to reduce the shock and stress they experienced during and after surgery. Huguenard had success with a combination of promethazine and pethidine, at the time under the trade names Diparcol and Dolossal, and told Laborit of his finding. Laborit thought that putting patients into a state of artificial hibernation would prevent some aspects of stress reactions. These drugs made bodies stop their reactions to cooling.

Laborit suggested to Rhône-Poulenc (a pharmaceutical company that became Sanofi) that they create antihistamines that optimized stabilization of the central nervous system. There, chemist Paul Charpentier headed a group trying to improve on the existing drug diphenhydramine (Benadryl, Dramamine, U.S. Sominex). So Charpentier created a new series of phenothiazines, one of them by adding a chlorine atom. Simone Courvoisier tested the series on laboratory rats and discovered that RP 4560 (chlorinated promazine, later known as chlorpromazine) could reverse the effects of epinephrine and could induce a state of apathy or indifference. Rhône-Poulenc marketed the drug in Europe for vomiting, pain, nausea, and convulsions as Largactil in 1952.

Lasker award Laborit shared the prestigious Lasker-DeBakey Clinical Medical Research Award in 1957 with Pierre Deniker and Heinz Lehmann for contributions towards the general use of chlorpromazine. No one won a Nobel Prize for the discovery,

Career Laborit became director of the Laboratoire d'Eutonologie at Boucicault Hospital in Paris. His interests included psychotropic drugs and memory.

Alexander Zaytsev synthesized GHB in 1874, and Laborit synthesized the drug in 1960. He was researching GHB as a precursor to the neurotransmitter GABA. Laborit published "Sodium 4-hydroxybutyrate" in the International Journal of Neuropharmacology in September 1964.

Awards and cultural references Laborit received the Croix de Guerre with distinction. He was elected a Chevalier of the Legion of Honor in 1953. He received the Lasker-DeBakey Clinical Medical Research Award which he shared in 1957, after traveling to the United States on behalf of Rhône-Poulenc.

Laborit's ideas are the substance of the Alain Resnais 1980 film Mon oncle d'Amérique in which he plays himself.

Laborit interviewed Salvador Dalí about one of his books which Dalí had read but did not understand.

Death and legacy

Healy wrote that Laborit felt cheated of his recognition and that he died a bitter man. Healy noted a few attempts to set the record straight: a 1980 book by Jean Thuillier that credits Delay and Deniker and Laborit, a 1960s book by Ann Caldwell that sided with Laborit, and a 1974 book by Judith Swazey, Chlorpromazine in Psychiatry, which gave credit to both sides. A 1992 commemoration by Rhône-Poulenc gave Laborit credit for anesthesia but gave Deniker and Delay credit for application of chlorpromazine to psychiatry. In 1994, on the 200th anniversary of the founding of Val-de-Grâce, a plaque was placed there commemorating the discovery of chlorpromazine by Laborit, Harmon, Paraire, and Velluz in 1952.

Laborit was one of the pioneers of complexity theory and self-organization in France and the initiator of "complex thought" in his meetings with the "Groupe des Dix". "Complex thought" was later popularized by Edgar Morin.

Publications

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