Fionula Brennan

Fionula Brennan (1957–2012) was an Irish immunologist and Professor of Cytokine Immunopathology at the Kennedy Institute of Rheumatology.

Brennan described the role of tumour necrosis factor (TNF) in rheumatoid arthritis by demonstrating that anti-TNF antibodies inhibit inflammation of the synovial joints. This research led directly to the development of anti-TNF therapy.

Early life and education Fionula Brennan was born in Manorhamilton, County Leitrim, to Josie and Ted Brennan in 1957. She had a brother and a sister.

Brennan received her undergraduate degree and PhD in immunology from the University of Bristol. Brennan was Professor of Cytokine Immunopathology at the Kennedy Institute of Rheumatology until 2011.

In the late 1980s, developments in knowledge about cytokine production and methods of study had made it possible to investigate further their role in rheumatoid arthritis. Since it remained unclear which cytokine should be targeted to produce therapeutic effects, they were not investigated as therapeutic targets. However, as a postdoctoral researcher working initially with Ravinder Maini and then under Marc Feldmann from 1988 to 1989, Brennan questioned whether it was possible to suppress pathologic TNF selectively. Her work developed upon that of Feldmann and Glenn Buchan.

Brennan's experiments analysed cytokine expression in a dissociated synovial cell culture model, which kept immune/inflammatory cells alive and made it possible to study disregulation.

Brennan's experiments provided the first evidence that TNF might be a therapeutic target. Brennan's work showed that rheumatoid mixed synovial cell cultures were distinct from osteoarthritic cell cultures because anti-TNF antibodies reduced production of IL-1 cytokines, which regulate immune and inflammatory responses.

Brennan spent the rest of her career building upon her significant early findings the importance of TNF overproduction in rheumatoid arthritis. She challenged the idea that T-cells were not relevant to rheumatoid arthritis by showing that TNF was produced by T-cell activated macrophages.

The Marc and Tania Feldmann Charitable Trust plan to commemorate Brennan by naming a grant in her honour.