Betsy James Wyeth

Betsy James Wyeth (née Betsy Merle James; 26 September 1921 – 21 April 2020) was an author and art collector. She was also the business manager and archivist of her husband, artist Andrew Wyeth. Their son, Jamie, later said "I always felt her signature should be alongside his." An artist like his son, the book helped to catalyze a reassessment of his career.

The Wyeths were significant benefactors in art and education. Wyeth also restored the old mill complex on the Brandywine River which became the couple's home and studio.

Betsy Wyeth was a founding member of the Chadds Ford Historical Society, and a driving force in the creation of Island Journal. In 1987, she founded Up East Incorporated, to support environmental research, preservation, and education in Maine.

Between 2020 and 2021, the Brandywine Museum of Art paid tribute to Betsy Wyeth's legacy with a display of 20 drawings and paintings of and about her. In 2022, The Farnsworth Museum in Rockland, Maine staged an exhibition titled Betsy's Gift. Since its formation in 2002, the Foundation has provided more than $10 million in financial support for art and artists.