Arnold Demain

Arnold L. Demain (April 26, 1927 – April 3, 2020) was an American microbiologist. During his 60-year career, he gained a reputation in the field of industrial microbiology. He was the Professor of Industrial Microbiology in the Biology Department at MIT and Founder and Head of Department of Fermentation Microbiology at Merck & Co. Demain was described as "one of the world's leading industrial microbiologists" and as "a scientist constantly in the forefront of industrial microbiology and biotechnology." He was "a pioneer in research on the elucidation and regulation of the biosynthetic pathways leading to the penicillins and cephalosporins" and "instrumental in the development of the beta-lactam industry". One feature of Demain's work, according to Microbiology Australia, was his "ability to undertake fundamental research on systems with clear industrial applications, recognising that biodiscovery is the start of the road that includes strain improvement to achieve levels of product synthesis that warrant further investment to take products into the marketplace." Demain published over 500 papers, co-edited or co-authored fourteen books, and took out 21 U.S. patents.

Demain attended Michigan State College briefly, then joined the U.S. Navy in 1945 and spent two years in Philadelphia caring for amputees who were members of the armed forces who had been injured in the war. Demain returned to Michigan State in 1947, earning B.S. and M.S. degrees in bacteriology from the Department of Microbiology and Public Health in 1949 and 1950 respectively. His master's research topic was the spoilage and softening of pickles during fermentation, a phenomenon that, he concluded, was probably caused by pectic enzymes.

Career In early 1954, Demain moved to Danville, Pennsylvania, where he worked as a research microbiologist for Merck Sharp & Dohme, studying the synthesis of penicillin. His work helped identify the amino acids that form the nucleus of penicillin, established the mechanisms that enable primary metabolites and carbon sources to regulate secondary metabolite synthesis, and demonstrated that penicillin was the product of synthesis and inactivation during fermentation. In 1971, he was involved with the Cetus Corporation and served as an advisor.

Personal life Arny Demain was married to Joanna (Kaye) Demain for 68 years; they had two children, Pamela and Jeffrey. He died from complications of COVID-19.