Anthony Pawson

Anthony James Pawson (18 October 1952 – 7 August 2013 ) was a British-born Canadian genetic scientist. He was known and recognized for his work on cellular organization, including how cells respond to growth signals, and how they communicate with each other.

He studied at the Winchester College and Clare College, Cambridge, where he received an MA in biochemistry followed by a PhD from King's College London in 1976. From 1976 to 1980 he pursued postdoctoral work at the University of California, Berkeley. From 1981 to 1985, he was assistant professor in microbiology at the University of British Columbia.

Pawson was a Distinguished Investigator and former Director of Research at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Professor in the Department of Molecular Genetics at the University of Toronto both of which he joined in 1985.

Pawson died on 7 August 2013 of unspecified causes at the age of 60.

Research

Pawson's research changed the understanding of signal transduction, the molecular mechanisms by which cells respond to external cues, and how they communicate with each other. He identified the phosphotyrosine-binding Src homology 2 (SH2 domain) as the prototypic non-catalytic interaction module. SH2 domains serve as a model for a large family of protein modules that act together to control many aspects of cellular signalling. Since the discovery of SH2 domains, hundreds of different modules have been identified in many proteins. 2004 – Louisa Gross Horwitz Prize from Columbia University 2004 – Poulsson Medal, the Norwegian Society of Pharmacology and Toxicology 2004 – Associate of the National Academy of Sciences (US) 2004 – Member of the American Academy of Arts and Sciences 2005 – Wolf Prize in Medicine "for his discovery of protein domains essential for mediating protein-protein interactions in cellular signaling pathways, and the insights this research has provided into cancer" 2005 – The Royal Medal (The Queen's Medal) from The Royal Society of London 2006 – Member of the Order of the Companions of Honour 2007 – Premiers Summit Award 2007 – Howard Taylor Ricketts Award from University of Chicago 2008 Kyoto Prize – "Japan's Nobel" for "Proposing and Proving the Concept of Adapter Molecules in the Signal Transduction" 2012 – Clarivate Citation Laureate 2012 – Thomson Reuters Citation Laureates, candidate for Nobel Prize in Medicine "for identification of the phosphotyrosine binding SH2 domain and demonstrating its function in protein-protein interactions" 2013 – Annual award of the Canadian National Proteomics Network, thereafter named the CNPN-Tony Pawson Proteomics Award