Alim-Louis Benabid

Alim Louis Benabid is a French-Algerian emeritus professor, neurosurgeon and member of the French Academy of Sciences, who has had a global impact in the development of deep brain stimulation (DBS) for Parkinson's disease and other movement disorders. He became emeritus professor of biophysics at the Joseph Fourier University in Grenoble in September 2007, and chairman of the board of the Edmond J. Safra Biomedical Research Center in 2009 at Clinatec, a multidisciplinary institute he co-founded in Grenoble that applies nanotechnologies to neurosciences. He received his medical degree in 1970 and a doctorate in physics in 1978, both from Joseph Fourier University (now part of the Université Grenoble Alpes) in Grenoble. Benabid also had a fellowship in 1979 – 1980 in preclinical neuropharmacology in the laboratory of Floyd Bloom at the Salk Institute in La Jolla, California. From 1988 to 2007, he directed the preclinical neurosciences unit at the French biomedical and public health research institution INSERM, and from 1989 to 2007, served as head of the neurosurgery department at the University Hospital of Grenoble. In 2009, he became chairman of the board of the Edmond J. Safra Biomedical Research Center at Clinatec, a translational biomedical technology organization he helped found within Minatec. Clinatec was jointly created by CEA-LETI (Laboratoire d'électronique des technologies de l'information—an applied micro- and nanotechnology subsidiary of CEA), Grenoble University Hospital, INSERM and Joseph Fourier University. In 2013, when awarding Benabid a $100,000 Robert A. Pritzker Prize for Leadership in Parkinson's Research to fund continued research, the Michael J. Fox Foundation said in its award announcement that Benabid had published 523 scientific papers, achieving an H Index of 67, as well as given 18 honorary lectures, and received 23 medals and prizes.

Parkinson's disease is commonly treated with medicines such as levodopa to improve muscle control, balance and walking, but higher dosages tend to be needed over time in this progressive neurological condition, and long-term use can lead to motor fluctuations such as tremor, rigidity or slowness.

Prior to development of DBS, the main surgical treatment for Parkinson's disease was lesioning to inhibit involuntary abnormal motion associated with severe Parkinson's disease not controlled by optimal medication. Initially he tested the thalamus, but switched to the subthalamic nucleus based on animal studies. As batteries and surgical technology advanced to allow such stimulation to be continuously applied for a long time, DBS became widely adopted in the 1990s for treatment of movement disorders such as Parkinson's disease, essential tremor, and dystonia.

A meta-analysis of six randomized controlled trials published in 2014 showed that in 1,184 study subjects, DBS significantly improved untreated motor symptoms of Parkinson's disease, permitting a reduction in medication doses and their associated complications; as well as contributing moderately, during the phase when the patients were taking Parkinson's disease medication, to fewer motor symptoms, greater function, and better quality of life.

Cancer research Outside of his work with DBS, Benabid also researched stereotactic surgery methods for brain surgery in patients who had brain tumors or certain types of movement disorders.

Honorary degrees Honorary degree, National University of Ireland, Galway (2005) Honorary degree, University of Western Ontario, London, Canada Honorary degree, McGill University, Montreal, Canada