Sebastian Amigorena

Sebastian Amigorena is an Argentine immunologist and a Team Leader at the Institut Curie.

Education and career Sebastian Amigorena was born in 1960 in Buenos Aires. He studied biochemistry at Paris Diderot University, earning his Ph.D. in 1990 under the supervision of Wolf H. Fridman, with a thesis titled "FcR expression in B lymphocytes". He then went on to a postdoctoral fellowship in the laboratory of Ira Mellman at Yale Medical School.

Research Amigorena's research focuses on antigen presentation by dendritic cells.

Notable works

Guermonprez P, Saveanu L... Amigorena S (2003). ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells. Nature. 425(6956): pgs. 397–402 Thery C, Boussac M... Amigorena S (2001). Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. Journal of Immunology. 166(12): pgs. 7309–7318 Regnault A, Lankar D... Amigorena S (1999). Fcy receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immuno complex internalization. Journal of Experimental Medicine. 189(2): pgs. 371–380 Thery C, Regnault A... Amigorena S (1999). Molecular characterization of dendritic cell-derived exosomes: selective accumulation of the heat shock protein hsc73. Journal of Cell Biology. 147(3): pgs. 599–610 Zitvogel L, Regnault A... Amigorena S (1998). Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nature Medicine. 4(5): pgs. 594-600