Maria Manaseina

Maria Mikhaĭlovna Manàsseina, also known as Marie de Manacéïne, was a neuroscientist who specialized in the area of sleep deprivation. She was born in Korkunova in 1841 and died in Saint Petersburg on 17 March in 1903. She was buried at the Novodévitxi cemetery. Manàsseina was the daughter of Mikhaïl Korkunov, a historian; her brother Nikolai Korkunov was a philosopher. She was the disciple of the professor Ivan Tarkhànov.

Manàsseina was one of the first women in the Russian Empire to graduate in medicine. She published numerous articles in French, Russian, and German under different names: Marie de Manacéïne, Maria Manàsseina, or Marie von Manassein. She was not uncommonly referred to as a male doctor. Despite her outstanding contributions, in the last ten years, her name has not been cited more than 100 times.

Personal life While still a student, Manàsseina married another student, Mr Poniatovsky. They participated alongside in the Narodniki revolutionary circles. As a control measure, they deprived other puppies of food. Even though they had been starving for 20–25 days, they could be rescued and returned to a healthy condition. These results clearly showed the importance of sleeping for life to be maintained and that sleep deprivation leads to a faster death than the deprivation of nutrients. Further research showed that the effects of sleep deprivation in the puppies included a body temperature decrease of four to six degrees, suggesting a halt in the homeostatis system as well as a reduction of the number of red blood cells, local brain hemorrhages, cerebral ganglion impairment, etc.

As a consequence of this research, Manàsseina concluded that sleeping is as necessary as nutrition for the regeneration of the brain cells. She also emphasized the idea that, during sleep, there is in the brain. This assertion challenged the prevailing belief at that time that sleeping was merely a passive state of the organism. She also stressed that only the brain structures involved in maintaining consciousness are inactive during sleep–thus, sleeping means resting the consciousness. This intuition is remarkable considering that the electroencephalogram didn't yet exist.

Her work had a great impact on the scientific community and many scientists replicated her model:

In 1896, the American psychologists George T.W. Patrick and J. Allen Gilbert conducted the first sleep deprivation experiment on humans. In 1898, Italian investigators Lamberto Daddi and Giulio Tarozzi and, separately, Cesare Agostini, expanded Manàsseina's findings by conducting detailed histopathologic and anatomic analyses of the puppies' brains.

Biochemistry

Though Manàsseina worked in Saint Petersburg the majority of her life, she spent several months at the Polytechnic Institute of Viena working alongside Jullius Wiesner. There, she made a noteworthy finding concerning the fermentation process, which was an important contribution to the field of biochemistry. Against the prevailing belief at that time, Manàsseina was the first to claim that the fermentation process is due to the action of enzymes that can be isolated from the yeast cells. Therefore, she concluded that yeast fermentation is a cell-independent process.

A few years later, Eduard Buchner replicated the results of this research and published them. Despite his being aware of Manàsseina's work, he considered her experiments to be unreliable and he did not cite her nor give her any credit. Despite her efforts to obtain recognition for this discovery, it was Buchner who received a Nobel Prize in 1907.

Publications Maria Manàsseina wrote the first book about medical problems related to sleep. This work addresses dreams as "evidence of a permanent psychic life generated by the brain during sleep". Nevertheless, her most outstanding publication is "Le Sommeil, tiers de notre vie" ("Sleeping, a third of the human life"), which was published in 1892.

L'anarchie passive et le comte Léon Tolstoï (1895)

Sommeil, tiers de notre vie, pathologie, physiologie, hygiène, psychologie (1896)