Lumír Krejčí

Lumír Krejčí (born 30 March 1972 in Slavičín) is a Czech biochemist. His research is focused on regulatory processes involved in maintaining genome integrity. Currently, as associate professor in biochemistry, he leads the laboratory of recombination and DNA repair (LORD) at the Department of Biology, Faculty of Medicine, at Masaryk University in Brno.

His laboratory has worked on understanding how Rad51 paralogs act during homologous recombination.

At Masaryk University, Lumír Krejčí organizes Mendel Lectures, a series of lectures given by the world's top scientists, and he is the founders of BIOSKOP - Research Education Center.

Publications His most cited papers are: Krejci L, Van Komen S, Li Y, Villemain J, Reddy MS, Klein H, Ellenberger T, Sung P. "DNA helicase Srs2 disrupts the Rad51 presynaptic filament." Nature. 2003 May;423(6937):305. Cited 558 times according to Google Scholar Papouli E, Chen S, Davies AA, Huttner D, Krejci L, Sung P, Ulrich HD. Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Molecular cell. 2005 Jul 1;19(1):123-33. Cited 486 times according to Google Scholar Recently his laboratory focuses also on identification of new anticancer compounds.

Laboratory of Recombination of DNA Repair (LORD) In 2005, Krejčí moved back to Brno, where he was appointed Principal Investigator, and later in 2012 Associate Professor. The main objectives of his lab's research are “to decipher the intrinsic functions of homologous recombination (HR) which has a dual role in the maintenance of genome stability. First, it promotes the faithful repair of DNA double-strand breaks (DSBs) belonging among of the most lethal forms of DNA damage. Moreover, HR is responsible for the creation of genetic variability during meiosis by directing the formation of reciprocal crossovers that result in random combinations of alleles and traits.” Rad59, PCNA ); (ii) elucidation of the molecular mechanism of the key step of HR, recombination-associated DNA synthesis; (iii) role of paralogues of RAD51 in promoting RAD51 filament stability

Currently, the laboratory focuses on two main topics, development of novel active compounds targeting diverse nucleases and understanding the regulation of RAD51 nucleofilament.

Personal life Lumír Krejčí is married to Kateřina Krejčí, with whom he has three children.