Leona D. Samson

Leona D. Samson is the Uncas and Helen Whitaker Professor and American Cancer Society Research Professor of Biological Engineering at the Massachusetts Institute of Technology, where she served as the director of the Center for Environmental Health Sciences from 2001 to 2012. Before her professorship at MIT, she held a professorship at the Harvard School of Public Health. She is on the editorial board of the journal DNA Repair. Her research interests focus on "methods for measuring DNA repair capacity (DRC) in human cells", research the National Institute of Health recognized as pioneering in her field, for which the NIH granted her the National Institutes of Health Director's Pioneer Award.

Education and career Samson received her Bachelor of Science degree in biochemistry from the University of Aberdeen in 1974. She was recognized by the NIH for her work in 2009, when she was awarded the National Institutes of Health Director's Pioneer Award, a funded grant awarded to "[support] individual scientists of exceptional creativity, who propose pioneering – and possibly transforming approaches – to major challenges in biomedical and behavioral research." Since 2007 she has been a fellow of the American Association for the Advancement of Science, "the world's largest general scientific society". She has also been elected Fellow of the National Academy of Medicine and the American Academy of Arts and Sciences.

Research area Samson specializes in bacterial, yeast, mouse and human DNA repair. Specifically, her lab's goal is to "understand the biology, the biochemistry, and the genetics of numerous DNA repair pathways that act upon DNA alkylation damage." Alkylating agents inhibit replication, transcription and protein synthesis and thus damage rapidly dividing cells, among which cancer cells are primarily affected because they divide so rapidly. She measures cells' ability to resist the toxicity caused by DNA-damaging agents, like alkylating agents. One of her most-cited articles, "Global response of Saccharomyces cerevisiae to an alkylating agent", measures the gene transcript levels of a yeast named Saccharomyces cerevisiae. Another highly cited article, also about Saccharomyces cerevisiae, was published in 2000 and entitled "Regulatory Networks Revealed by Transcriptional Profiling of Damaged Saccharomyces cerevisiae Cells: Rpn4 Links Base Excision Repair with Proteasomes." This paper finds that the transcription and repair of certain genes in the yeast are regulated by the proteasome-associated protein Rpn4.

Awards American Cancer Society Scholar Award (1985) American Cancer Society Faculty Research Award (1987) Burroughs Wellcome Toxicology Scholar Award (1993) AACR Women in Cancer Research Award (2000) Environmental Mutagen Society Annual Award for Research Excellence (2001) American Cancer Society Research Professor (2001) Elected member of the National Academy of Medicine (NAM) (2003) Elected President of the Environmental Mutagen Society (2004) Elected Fellow of the American Association for the Advancement of Science (AAAS) (2007) NIH Director's Pioneer Award (2009) Senior Scholar Award from the Ellison Medical Foundation (2012) Fellow of the Radcliffe Institute for Advanced Study (2014–15) Elected Fellow of the American Academy of Arts and Sciences (2021)

Personal life Samson married David Hunter, the dean for academic affairs and current acting dean of the faculty at the Harvard School of Public Health, on August 5, 1989. They adopted their daughter, Claire, in 1994.