Kenneth Stewart Cole

Kenneth Stewart Cole (July 10, 1900 – April 18, 1984) was an American biophysicist described by his peers as "a pioneer in the application of physical science to biology". He was awarded the National Medal of Science in 1967.

Biography He was born on July 10, 1900, in Ithaca, New York, to Charles Nelson Cole, an instructor in Latin at Cornell University and Mabel Stewart. Kenneth had a younger brother, , with whom he remained very close throughout his life despite a large difference in age; they were joint authors of four papers published between 1936 and 1942.

Kenneth joined the staff of Columbia University in 1937 and remained there until 1946. He had also been associated with the Presbyterian Hospital, and the Guggenheim Foundation for Advanced Study at Princeton University and the University of Chicago.

From 1949 to 1954 he was the technical director of the Naval Medicine Research Institute in Bethesda, Maryland. In 1954 he became chief of the laboratory of biophysics of the National Institute of Neurological Diseases and Blindness.

He achieved advances that led to the "sodium theory" of nerve transmission that later won Nobel Prizes for Alan L. Hodgkin and Andrew F. Huxley in 1963. Cole was elected a Fellow of the American Physical Society in 1931, a member of the National Academy of Sciences in 1956, and a Fellow of the American Academy of Arts and Sciences in 1964. He was awarded the National Medal of Science in 1967, the award citation, read: "As a result, we know far more about how the nervous system functions." In 1972 he was made a member of the Royal Society of London. The Biophysical Society awards the Kenneth S. Cole medal to a scientist studying cell membranes.

In 1980 he became an adjunct professor of the Department of Neurosciences at the Scripps Institute of Oceanography in San Diego. He had a son, Roger Braley Cole, and a daughter, Sarah Roberts Cole.

He died on April 18, 1984, in La Jolla, California. The impedance is given by:

Where and are the resistances at zero frequency (i.e. DC) and infinity, respectively. is often referred to as the characteristic frequency. The characteristic frequency is not the same when the analysis is carried out in terms of the complex permittivity. A simple interpretation of the above equation is in terms of a circuit where a resistance is in series with a capacitor and this combination is placed in parallel with a resistance . In this case and . It can be shown that is given by .

Electrical measurements of tissues In a series of papers in 1930s—1940s, he experimentally studied the electric properties of living tissues, such as Nitella, frog eggs, and most famously, the squid giant axon.

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