James R. Downing

James R. Downing is an American clinical executive. He is the president and chief executive officer of St. Jude Children's Research Hospital.

Early life and education James R. Downing was born to Lillian and Robert W. Downing and grew up in Detroit, Michigan with five siblings. Downing enjoyed playing football and baseball while he attended Aquinas High School, and initially hoped to play baseball professionally. He received his bachelor's degree from the University of Michigan-Dearborn, where he initially majored in engineering before switching to biochemistry. He attended the University of Michigan to earn a Doctor of Medicine in 1981.

Career Following his Doctor of Medicine, Downing completed a 2-year medical residency in anatomic pathology, working at Barnes Hospital and The Jewish Hospital of St. Louis at Washington University in St. Louis. In 1984, he completed a fellowship in hematopathology at the University of Florida

Downing was one of the inaugural co-editors of the Annual Review of Pathology: Mechanisms of Disease, though he only held the position for the first volume in 2006. He has also served on the editorial boards of Cancer Discovery, Cancer Cell, and Oncogene.

In 2010, Downing launched the Pediatric Cancer Genome Project in an effort to determine the genetic lesions that underlie childhood cancers. By 2013, the project had sequenced the genomes of over 700 pediatric cancer patients and 21 different types of cancer.

In 2018, Downing led St. Jude Children’s Research Hospital in partnering with the World Health Organization to create the first WHO Collaborating Centre for Childhood Cancer and start a Global Initiative for Childhood Cancer, working with over 50 governments worldwide. In December 2021, they announced the Global Platform for Access to Childhood Cancer Medicines, to increase access to cancer medicines for the nearly 90% of children with cancer who live in low and middle income countries (LMICs). The project will provide medicines to countries at no cost during the pilot phase.

Awards honors 1998, Member, American Society for Clinical Investigation 2003. Member, Association of American Physicians 2003, Member, American Association for the Advancement of Science. 2005, Philip Levine Award for Outstanding Research, American Society for Clinical Pathology 2012, Award for Excellence in Molecular Diagnostics, Association for Molecular Pathology 2013, Member, Institute of Medicine (now the National Academy of Medicine) 2016, Member, American Academy of Arts and Sciences 2017, Society of Memorial Sloan Kettering Prize, 2019, Pediatric Oncology Award, American Society of Clinical Oncology 2020, Inaugural AACR-St. Baldrick’s Foundation Award for Outstanding Achievement in Pediatric Cancer Research, American Association for Cancer Research 2022, Fellow of the American Association for Cancer Research in recognition of his contributions to the Pediatric Cancer Genome Project.

Personal life James R. Downing is married to Mariea Downing; the couple has three children and six grandchildren.