Daniela M Ferreira

Daniela M. Ferreira is a Brazilian British immunologist. She is a specialist in bacterial infection, respiratory co-infection, mucosal immunology and vaccine responses. She is currently Professor of Respiratory Infection and Vaccinology at the Oxford Vaccine Group in the Department of Paediatrics at the University of Oxford and the Director of the Liverpool Vaccine Group at the Liverpool School of Tropical Medicine. She leads a team of scientists studying protective immune responses against pneumococcus and other respiratory pathogens such as SARS-CoV2. Her team has established a novel method of inducing pneumococcal carriage in human volunteers.

Ferreira is part of the HIC-VAC consortium and Leads the WorkStream on Human Challenge Plataform to accelerate product development in the UKRI Infection Innovation Consortium .

Research and career Ferreira obtained a Degree and Bachelor's Degree in Biological Sciences in 2005 and a Ph.D. in Immunology in 2009, both from the University of São Paulo (São Paulo, Brazil). During her PhD, Ferreira was awarded the Robert Austrian Research Award in Pneumococcal Vaccinology.

Ferreira joined the Respiratory Infection group at Liverpool School of Tropical Medicine as a postdoctoral fellow in December 2009 and together with Prof. Stephen Gordon led the development of an Experimental Human Pneumococcal Nasopharyngeal Colonization Model. Ferreira was appointed Professor and subsequent Head of Department of Clinical Sciences in 2018. Mitsi. E, Carniel.B, Reiné.J, Rylance.J, Zaidi. S, Soares-Schanos.A, Connor. V, Collins. A, Schlitzer. A, Nikolaou. E, SolorzanoGonzalez. C, Pojar. S, Hill. H, Hyder-Wright. A, Jambo. K, Oggioni. M. De Ste Croix, Megan, Gordon.S, Jochems.S, and Ferreira. DM. Nasal Pneumococcal Density is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens. Am J Respir Crit Care Med. Oct 2019.https://doi.org/10.1164/rccm.201903-0607OC. Jochems S, K.de Ruiter, C.Solórzano, A. Voskamp, E.Mitsi, E.Nikolaou, B.Carniel, S. Pojar, E.German, J. Reiné, A. Soares-Schanoski, H. Hill, R.Robinson, A. Hyder-Wright, C. M. Weight, P.F. Durrenberger, R.S. Heyderman, S. B. Gordon, H. H. Smits, B.C. Urban, J. Rylance, A.. Collins, M. D. Wilkie, L.Lazarova, S.C. Leong, M.Yazdanbakhsh, Ferreira DM. Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization, J Clin Invest. 2019, Oct;129(10):4523-4538. Steenhuijsen Piters WAA, Jochems S, Mitsi E, Rylance J, Pojar S, Nikolaou E, German EL, Holloway M, Carniel BF, Chu MLJN, Arp K. Sanders EAM, Ferreira DM* and Bogaert D.* Interaction between live-attenuated influenza vaccine, Streptococcus pneumoniae and the nasal microbiota. Nat Commun. 10, 2981 (2019), https://doi.org/10.1038/s41467-019-10814-9.

Pennington SH, Pojar S, Mitsi E, Gritzfeld JF, Nikolaou E, Solórzano C, Owugha JT, Masood Q, Gordon MA, Wright AD, Collins AM, Miyaji EN, Gordon SB, Ferreira DM. Polysaccharide-specific Memory B-cells Predict Protection Against Experimental Human Pneumococcal Carriage. Am J Respir Crit Care Med. 2016 Dec 15;194(12):1523-1531. E Mitsi, AM Roche, J Reiné, T Zangari, JT Owugha1, SH Pennington, JF Gritzfeld, AM Collins, S van Selm, MI de Jonge, SB Gordon, JN Weiser, DM Ferreira. Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage. Mucosal Immunol. 2016 Aug 31. doi: 10.1038/mi.2016.71. Glennie S, Gritzfeld JF, Pennington SH, Garner-Jones M, Coombes N, Hopkins MJ, Vadesilho CF, Miyaji EN, Wang D, Wright AD, Collins AM, Gordon SB, Ferreira DM. Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage. Mucosal Immunol. 2016 Jan;9(1):56-67. doi: 10.1038/mi.2015.35. Ferreira DM, Neill DR, Bangert M, Gritzfeld JF, Green N, Wright AK, Pennington SH, Moreno LB, Moreno AT, Miyaji EN, Wright AD, Collins AM, Goldblatt D, Kadioglu A, Gordon SB. Controlled Human Infection and Re-Challenge with Streptococcus Pneumoniae Reveals the Protective Efficacy of Carriage in Healthy Adults. Am J Respir Crit Care Med. 2013 Jan 31.