Ardem Patapoutian

Ardem Patapoutian (, ; born 1 October 1967) is a Lebanese-American molecular biologist, neuroscientist, and Nobel Prize laureate of Armenian descent. He is known for his work in characterizing the PIEZO1, PIEZO2, and TRPM8 receptors that detect pressure, menthol, and temperature. Patapoutian is a neuroscience professor and Howard Hughes Medical Institute investigator at Scripps Research in La Jolla, California. In 2021, he won the Nobel Prize in Physiology or Medicine jointly with David Julius. His father, Sarkis Patapoutian (better known by the pen name ), is a poet and an accountant, while his mother, Haiguhi Adjemian, was the principal of an Armenian school in Beirut. He has a brother, Ara, and a sister, Houry. His grandparents settled in Lebanon from Hadjin after surviving the Armenian Genocide.

He is childhood friends with journalist and author Vicken Cheterian. He attended the Demirdjian and Hovagimian Armenian schools in Beirut. In 1986, Patapoutian and his brother immigrated to the United States as refugees. Once in the United States, Patapoutian worked odd jobs, such as delivering pizzas and writing horoscopes for an Armenian newspaper, as he established residency in the state of California.

He received a B.S. degree in cell and developmental biology from the University of California, Los Angeles in 1990 and a PhD degree in biology from the California Institute of Technology in 1996 under direction of Barbara Wold.

As a postdoctoral fellow, Patapoutian worked with Louis F. Reichardt at the University of California, San Francisco. In 2000, he became an assistant professor at Scripps Research (then known as The Scripps Research Institute). Since 2014, Patapoutian has been an investigator for the Howard Hughes Medical Institute (HHMI).

Research Patapoutian's research is into the biological receptors for temperature and touch (nociception). The discoveries made it possible to understand how heat, cold and mechanical forces trigger nerve impulses. The channel for the sense of touch was called PIEZO1 . This ion channel, the more important of the two mechanoreceptors, is essential for the sense of touch. PIEZO1 and PIEZO2 channels have been shown to regulate additional important physiological processes including blood pressure, respiration and urinary bladder control. Patapoutian and his collaborators were able to show that these ion channels play an outstanding role in the sensation of temperature, in the sensation of touch, in proprioception, in the sensation of pain and in the regulation of vascular tone. More recent work uses functional genomics techniques to identify and characterize mechanosensitive ion channels (mechanotransduction).

Awards and honors

Patapoutian has an h-index of 68 according to Google Scholar, and of 63 according to Scopus . He has been a Fellow of the American Association for the Advancement of Science since 2016, a member of the National Academy of Sciences since 2017 and of the American Academy of Arts and Sciences since 2020.

In 2017, Patapoutian received the W. Alden Spencer Award, in 2019 the Rosenstiel Award, in 2020 the Kavli Prize for Neuroscience, and the BBVA Foundation Frontiers of Knowledge Award in Biology / Biomedicine.

In 2021, he was awarded the Nobel Prize in Physiology or Medicine jointly with David Julius for their discoveries of receptors for temperature and touch.

In October 2021 President of Lebanon Michel Aoun awarded Patapoutian the Lebanese Order of Merit.

In 2022, Patapoutian was named by Carnegie Corporation of New York as an honoree of the Great Immigrants Award.

Recognition in Armenia Patapoutian, the first Armenian Nobel laureate, received a hero's welcome when he visited Armenia in June 2022. Prime Minister Nikol Pashinyan awarded him the Order of St. Mesrop Mashtots, while the Armenian National Academy of Sciences elected him an honorary member, and the Yerevan State Medical University awarded him an honorary doctorate. Patapoutian gifted a replica of his Nobel medal to the History Museum of Armenia. HayPost issued a stamp dedicated to him.

Selected publications PIEZO1 + PIEZO2

PIEZO2