William Bachovchin

William W. Bachovchin is an American chemist/chemical biologist, academic and researcher. He is a professor of Molecular and Chemical Biology at Tufts University School of Medicine, and the founder of three biopharmaceutical companies: Point Therapeutics, Arisaph Pharmaceuticals, and Bach BioSciences.

Bachovchin has published over 100 articles, and is the inventor of 58 issued US patents. His research has focused primarily on a family of proteolytic enzymes known as the serine proteases and has ranged from studies of their catalytic mechanisms at the molecular level, to identifying their biological functions, to the design and development of drugs targeting them. His work has made extensive use of NMR spectroscopy, mutagenesis, chemical synthesis, and in vivo testing of drug candidates in animal models.

Education Bachovchin attended Wake Forest University, from which he received his B.S. degree in Biology in 1970, and completed his Graduate Studies in Chemistry in 1972. He then earned his PhD in chemistry from the California Institute of Technology in 1977, under the supervision of John H. Richards. Following this, he served as a Postdoctoral fellow at The California Institute of Technology with John D. Roberts until 1978, and at Harvard Medical School with Bert L. Vallee until 1979.

Another notable early contribution includes resolving a discrepancy between results obtained by X-ray diffraction of an enzyme in the crystalline state versus results obtained by NMR spectroscopy of the enzyme in the solution state. He resolved the dispute by examining both states by NMR spectroscopy. The results confirmed crystalline and solution state enzymes did indeed differ and explained why they differed.

In the area of Engzymology, Bachovchin obtained direct evidence for a hydrogen bond involving a carbon-bonded proton as the hydrogen bond donor in an enzyme active site using NMR spectroscopy. On the basis of this discovery, his research team proposed a new mechanism, dubbed "the reaction-driven ring flip".

Drug design and discovery Bachovchin's work in the area of drug design and development has led to the design, synthesis and characterization of specific substrates and inhibitors for a number of enzymes including all members of the DASH family of enzymes. He designed, synthesized and characterized high potency inhibitors of DPP4 and then used them to interrogate the biological function of DPP4, work which demonstrated that DPP4 inhibitors had blood glucose lowering activity and therefore the potential for the treatment of diabetes. More recently his work has shown that DPP8/9 inhibitors trigger an immune response. He also designed, synthesized, and characterized specific substrates and inhibitors for Fibroblast Activation Protein (FAP), and has shown that the FAP-specific substrates can be used to deliver anticancer agents specifically to tumors while FAP-specific inhibitors can be used to deliver radioactive metals specifically to tumor for imaging or for therapy.

Awards and honors 1983–1988 – Research Career Development Award, National Institutes of Health (NIH) 2020 – Inducted into National Academy of Inventors