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Tshepo Motsepe

b. 1953

First Lady of South Africa

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About Tshepo Motsepe

Born 1953. Tshepo Motsepe is a South African politician.

Tshepo Motsepe (born 17 June 1953) is a South African physician and businesswoman. She is the First Lady of South Africa, as the wife of Cyril Ramaphosa, the President of South Africa. She is the older sister of Bridgette Radebe and her brother is Patrice Motsepe.

Biography Tshepo Motsepe studied as a medical doctor at the University of KwaZulu-Natal and completed her master's in public health at the Harvard School of Public Health. In 2012, she completed a Social Entrepreneurship Certificate Program (SECP) at the Gordon Institute of Business Science. She is the current chairperson of the African Self Help Trust (ASHA Trust), focusing on early childhood development and education.

Motsepe has worked in both public and private practice in Mmakau, Mahikeng, Johannesburg, Pretoria, and in Zimbabwe used to be a doctor at Parirenyatwa Hospital before she married the President of South Africa (Cyril Ramaphosa)and she the owner Delta Gold Zimbabwe. She is a former Deputy Director of The Reproductive Health Research Institute.

Family Motsepe is married to Cyril Ramaphosa, President of the Republic of South Africa, with whom she has four children. Motsepe is Ramaphosa's third wife. Her father is the late Chief Augustine Butana Chaane Motsepe, who was married to her mother Margaret Martha Keneilwe Motsepe her brother is the mining magnate Patrice Motsepe, and her sister Bridgette Radebe, wife of African National Congress (ANC) politician and former Minister of Energy Jeff Radebe.

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Important facts

Birth century
Occupation
Nationality
Education
Harvard T.H. Chan School of Public Health, University of KwaZulu-Natal, Harvard School of Public Health
Positions held
First Lady of South Africa

Family & relationships

Spouse
Cyril Ramaphosa

People in Tshepo Motsepe's life

Named in this biography and alive at the same time

Contemporaries

People whose lives overlapped Tshepo Motsepe's

Frequently asked questions

Who is Tshepo Motsepe?

First Lady of South Africa

When was Tshepo Motsepe born?

Tshepo Motsepe was born on 17 June 1953 in Soweto.

What is Tshepo Motsepe's occupation?

Tshepo Motsepe is a politician.

What nationality is Tshepo Motsepe?

Tshepo Motsepe is South African.

Sources & further reading

· Wikipedia: Tshepo Motsepe

· Wikidata: Q24234163

· DBpedia: Tshepo Motsepe

Cite this page

APA: Biography.guide. (2026). Tshepo Motsepe. https://biography.guide/tshepo-motsepe/

MLA: "Tshepo Motsepe." Biography.guide, https://biography.guide/tshepo-motsepe/.

Chicago: "Tshepo Motsepe." Biography.guide. https://biography.guide/tshepo-motsepe/.

Data last updated: 2026-09-20 · Spot an error? Report a correction.

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