Reuben J Shaw

Reuben Shaw is an American cancer researcher. He is a professor and director of the National Cancer Institute-Designated Cancer Center at the Salk Institute for Biological Studies, one of the NCI's seven basic laboratory cancer centers in the United States. He researches signaling pathways that control tumor metabolism, with a specific focus on an ancient energy-sensing pathway that controls biological response to starvation.

Education Reuben Shaw grew up in New York state, where he later earned a degree in biology from Cornell University. Shaw then earned his Ph.D. in cancer biology at Massachusetts Institute of Technology with advisor Tyler Jacks. He completed his postdoctoral fellowship at Harvard Medical School with advisor Lewis C. Cantley.

Career and research In 2004, Reuben Shaw discovered a link between primitive energy-sensing AMP-activated protein kinase and tumor suppressing Lkb1. Since then, he has researched AMPK, its downstream targets, and how its molecular pathway functions in relation to diabetes and cancer.

Shaw joined the Salk Institute for Biological Studies as an assistant professor in 2006. A non-small-cell lung cancer altered AMPK pathway can be reinitiated by treatment with the type 2 diabetes medication Metformin.

Shaw uses a combination of genetic engineering in mice and interdisciplinary studies across cancer, diabetes, neurodegenerative disease, and aging. His research contributes to the development of therapeutic solutions to cancers and metabolic diseases, such as the pivot of Metformin to potentially treat cancers and the identification of LKB1 as a target for non-small-cell lung cancer treatments.

Awards and honors

Clarivate Top Cited Researcher, 2019, 2020, 2021, 2022, 2024, 2025 Member of Lustgarten Advancing Breakthrough Science Program, 2022 Mark Foundation for Cancer Research Endeavor Award, 2022 Curebound Discovery Grant, 2022, and member of Scientific Advisory Board NCI Outstanding Investigator Award, 2017 Howard Hughes Medical Institute Early Career Scientist, 2009 The V Foundation for Cancer Research Scholar Award, 2006