Nako Nakatsuka

Nako Nakatsuka is a Japanese researcher and Assistant Professor of Neurotechnology at EPFL. Her research is focused on pioneering translational technologies that directly impact human health. Her research group, the Laboratory of Chemical Nanotechnology (CHEMINA) works at the intersection of chemistry, engineering, and neuroscience to develop innovative strategies to support patients suffering from neurodegenerative diseases. She was awarded the 2023 Prix Zonta.

Early life and education Nakatsuka was born in Osaka. She enrolled at the International School of the Sacred Heart, which was an all-girls' English-speaking school. She has said that at Fordham University she was inspired by Ipsita Banerjee. She was a doctoral researcher at University of California, Los Angeles, where she worked alongside Paul Weiss and Anne M. Andrews. She used chemical lift-off lithography and microfluidics to pattern small molecules in specific locations, which allowed for quantification of specific binding. She developed on-chip sensors for calculation of equilibrium dissociation constants.

Research and career Nakatsuka develops sensors that could be used to detect chemical changes in the brain that could be indicative of neurodegenerative disease and depression. Her sensors could be used to differentiate between similar molecules, e.g. neurotransmitters, precursors and metabolites. Nakatsuka used a DNA-based aptamer, which has a specific affinity for serotonin. Serotonin is critical in sleep and appetite, and is impacted by depression and obsessive–compulsive disorder. She was awarded the 2023 ETH Zurich Prix Zonta, which supports women scientists and professors. In 2024 she was awarded the Fondation Philanthropique Famille Sandoz prize to develop neurochemical biosensors for monitoring neurological disease.

Awards and honours

2021 Innovators Under 35 2023 ETH Zurich Prix Zonta 2024 Fondation Philanthropique Famille Sandoz Prize

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