Mary O'Riordan

Mary X. D. O’Riordan is an American molecular biologist who is the Frederick C. Neidhardt Collegiate Professor of Microbiology and Immunology at the University of Michigan. She also serves as Dean for Graduate and Postdoctoral Studies at Michigan Medicine.

Early life and education O'Riordan earned an undergraduate degree in biology from the University of Washington and an M.A. in molecular biology from Princeton University, then joined the University of California, San Francisco as a doctoral researcher. Her research considered early B cell differentiation. After earning her doctorate, O'Riordan moved to the University of California, Berkeley as a postdoctoral fellow. She is particularly interested in the mechanisms that underpin how the Gram-positive bacterium Listeria monocytogenes interacts with the cellular environment. She is also interested in how the pathogens regulate infection.

O'Riordan discovered the endoplasmic reticulum becomes stressed during lupus, which activates ERN1. ERN1 released neutrophil extracellular traps from lupus neutrophils, which trigger autoantibody formation and contribute to blood vessel clotting. In 2014, O'Riordan was named a Kavli Foundation fellow. In June 2015, O'Riordan was appointed Dean of Graduate & Postdoctoral Studies at the University of Michigan Medical School. She was named the Frederick C. Neidhardt Collegiate Professor in 2018.

Selected publications