Lewis B. Sheiner

Lewis B. Sheiner (1940 – April 22, 2004) was an American pharmacologist, known for his seminal work developing and applying mathematical models to problems in pharmacodynamics and pharmacokinetics.

Early life and education Born in New York City in 1940, Lewis B. Sheiner received his Bachelor of Arts degree with Honors in Chemistry from Cornell University in 1960 and earned his Doctor of Medicine (M.D.) from the Albert Einstein College of Medicine in 1964.

Career After earning his M.D., Sheiner did a three-year stint at Columbia Presbyterian Medical Center, first as an intern and then as a resident. "Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models" co-written with Nick Holford in 1981, and "Learning versus confirming in clinical drug development" in 1997.

Awards and honors Sheiner received the Oscar B. Hunter Award, the highest honor of the American Society for Clinical Pharmacology and Therapeutics (ASCPT), in 2004. and the ASCPT's Sheiner-Beal Pharmacometrics Award.

Death Sheiner died on April 22, 2004, at the age of 63, after experiencing cardiac arrhythmias while traveling by train from a scientific workshop in Sils Maria, Switzerland.