Isaac Sello Seitlholo

Isaac Sello Seitlholo (born 9 September 1989) is a South African politician, a Member of Parliament (MP) for the Democratic Alliance, and the former Deputy Minister of Water and Sanitation. He was the Shadow Minister of Public Works and Infrastructure in the DA's Shadow Cabinet.

Background Isaac Sello Seitlholo was born into a Tswana family on 9 September 1989. He matriculated from Tlokwe Secondary School in 2008. He holds a BA degree and a BA Honours degree in Development and Management and also a master's degree in Public Management and Governance from the North-West University. In parliament, he serves on the Portfolio Committee on Transport.

In November 2020, Seitlholo declared his candidacy for deputy provincial leader of the DA. He lost to Freddy Sonakile at the party's provincial congress.

Seitlholo was promoted to Shadow Minister of Public Works and Infrastructure on 21 April 2023.

Seitlholo returned to Parliament following the 2024 general election. Thereafter, the DA entered into a coalition agreement with the ANC which saw Seitlholo appointed as the Deputy Minister of Water and Sanitation.

On 17 June 2026, DA leader Geordin Hill-Lewis requested that president Cyril Ramaphosa remove Seitlholo as the Deputy Minister of Water and Sanitation. Ramaphosa finalised Hill-Lewis's request on 30 June.