Isaac Guerendo

Isaac Guerendo (; born June 28, 2000) is an American professional football running back and kickoff returner for the San Francisco 49ers of the National Football League (NFL). He played college football for the Wisconsin Badgers and Louisville Cardinals.

Early life Guerendo was born in Clayton, Indiana and attended Avon High School in Avon, Indiana. As a junior, he hauled in 19 receptions for 596 yards and six touchdowns. Guerendo had a breakout senior season, bringing in 54 receptions for 1,258 yards and 16 touchdowns. As a senior, he was named the Indianapolis Star's Mister Football for wide receivers.

College career Wisconsin In Guerendo's first season in 2019, he carried the ball once for one yard, while also making one catch for three yards, and returning one kickoff for 49 yards.

During the COVID shortened 2020 season, Guerendo carried the ball 11 times for 36 yards.

In Week 2 of the 2021 season, Guerendo recorded his first career touchdown on an 82-yard run versus Eastern Michigan. He finished the season with 160 yards and a touchdown of 23 carries, while also racking up two receptions for six yards.

In 2022, Guerendo rushed for 385 yards and five touchdowns on 64 carries, while also notching 17 receptions for 115 yards and a touchdown. At the end of the season, Guerendo decided to enter the NCAA transfer portal.

Guerendo finished his Wisconsin Badger career playing in 20 games carrying the ball 99 times for 582 yards and six touchdowns, while also notching 20 receptions for 124 yards and a touchdown. He graduated from Wisconsin in December 2022 with a bachelor's degree in personal finance.

Louisville In 2023, Guerendo became a graduate transfer to the University of Louisville, playing for the Louisville Cardinals for his final season of college eligibility. In his Louisville home debut in Week 2 of the 2023 season, Guerendo rushed for 63 yards and a touchdown on 11 carries, while also hauling in four receptions for 47 yards. In Week 10, he had a career performance rushing for 146 yards and three touchdowns in a win over Virginia Tech. In the 2023 Holiday Bowl, Guerendo rushed for a career high 161 yards and three touchdowns, on 23 carries, but the Cardinals lost to USC 42–28.

Guerendo finished the 2023 season with 810 yards and 11 touchdowns on 132 carries, while also making 22 receptions for 234 yards. After the season, he declared for the 2024 NFL draft.

Professional career

Guerendo was drafted by the San Francisco 49ers in the fourth round (129th overall) of the 2024 NFL draft. In May, he signed his four-year rookie contract with the 49ers. After injuries to running backs Christian McCaffrey and Jordan Mason, Guerendo had some playing time, making his debut in the Week 2 23–17 road loss the Minnesota Vikings. He scored his first NFL touchdown on a four-yard rush during the Week 8 30–24 victory over the Dallas Cowboys, along with 102 scrimmage yards.

NFL career statistics Legend Bold Career high

Regular season Year Team Games Rushing Receiving Kick returns Fumbles 2024 SF 16 3 84 420 5.0 76 4 15 152 10.1 40 0 6 163 27.2 35 0 3 1 2025 SF 14 0 – – – – – – – – – – 5 100 20.0 25 0 0 0 Career 30 3 84 420 5.0 76 4 15 152 10.1 40 0 11 263 23.9 35 0 3 1

Personal life Guerendo was born in Indianapolis to Mario and Jennifer Guerendo. Mario is an emigrant from the Central African Republic, and Jen competed in track & field in high school.