Ihor R. Lemischka

Ihor R. Lemischka was an American stem cell biologist and stem cell research advocate and was both the Lillian and Henry M. Stratton Professor of Gene and Cell Medicine and Director of the Black Family Stem Cell Institute at Mount Sinai Medical Center in New York City.

His work with hematopoietic stem cells (HSC) was the first to identify their novel receptor tyrosine kinases and showed that HSC can rebuild all blood cell types in a mouse whose blood cells had been destroyed.

He authored over 70 book chapters and publications in peer-reviewed journals.

Biography

Education and post-doctoral training Lemischka graduated from Johns Hopkins University in 1976 and earned his Ph.D. in biology from MIT in 1983. He did his post-doctoral training at MIT's Whitehead Institute.

Academic appointments Lemischka joined Princeton University in 1986 as Assistant Professor of Molecular Biology; he became Professor in 2002. Patent Number Title 7465464 Populations of cells that express flk-2 receptors 7445798 Populations of cells that express FLK-1 receptors 6960446 Method for isolating cells expressing flk-2 6677434 Soluble human flk-2 protein 6613565Use of delta-like protein to inhibit the differentiation of stem cells 5912133 Method for isolating stem cells expressing flk-1 receptors 5747651 Antibodies against tyrosine kinase receptor flk-1 5621090 Nucleic acids encoding soluble human FLK-2 extracellular domain 5548065 Tyrosine kinase receptor human flk-2-specific antibodies 5367057 Tyrosine kinase receptor flk-2 and fragments thereof 5283354 Nucleic acids encoding hematopoietic stem cells receptors flk-1 5270458 Nucleic acids encoding fragments of hematopoietic stem cell receptor flk-2 5185438 Nucleic acids encoding hencatoporetic stem cell receptor flk-2

Areas of concentration Lemischka's interests included defining the cellular and molecular mechanisms that control cell fate decisions in embryonic stem cells. Research into mouse embryonic stem cells was aggressively studied in the embryonic stem cells of humans.

Publications Partial List: