Hanna Mikkola

Hanna K.A. Mikkola is a Finnish-American physician who is Professor of Molecular, Cell and Developmental Biology a University of California, Los Angeles. Her research investigates the generation of blood stem cells during embryonic development. She looks to develop blood stem cell based treatments for leukemia.

Early life and education Mikkola completed her medical doctorate at the University of Helsinki. She remained there for her doctoral research, when she studied hemophilia. In particular, Mikkola was interested in the molecular basis of coagulation factor XIII. After earning her doctorate, Mikkola moved to the University of Lund as a postdoctoral fellow. She spent three years in Sweden before joining Harvard Medical School.

Research and career Mikkola develops blood stem cells (hematopoietic stem cells ) that can be used as treatments for blood cancers and immune disorders. Mikkola looks to understand the mechanisms that regulate the development of stem cells (blood stem cells and cardiovascular stem cells). She looks to identify pathways to make human embryonic stem cells to generate blood stem cells. The self-renewal and specification mechanisms are involved in leukemogenesis, a process that causes mutations of blood stem cells and results in leukemia. She studies the transcriptional regulatory network (TRN) involved in the development of blood cells, Understanding TRNs will help to uncover the pathways that are impacted by leukemia and develop more effective treatments.

Selected publications