Guoping Feng

Guoping Feng is a Chinese-American neuroscientist. He is the Poitras Professor of Neuroscience at the McGovern Institute for Brain Research in the Department of Brain and Cognitive Sciences at MIT and member of the Stanley Center for Psychiatric Research at Broad Institute. He is most notable for studying the synaptic mechanisms underlying psychiatric disease. In addition to developing many genetic-based imaging tools for the study of molecular mechanisms in the brain, he has generated and characterized rodent models of obsessive-compulsive disorder, autism spectrum disorders, and schizophrenia. Feng has also shown that some autism-like behaviors can be corrected in adult mice by manipulating the expression of the SHANK3 gene.

Education Feng received his PhD from SUNY Buffalo. He conducted his postdoctoral work at Washington University School of Medicine. Prior to joining the McGovern Institute in 2010, Feng was a faculty member at Duke University. In 2019, Feng and Zhigang He demonstrated that increasing myelination with the drug clemastine fumarate could reverse myelin deficits and hypersociability symptoms in mice lacking GTF2I, which may be translatable to human patients.

Awards and honors Beckman Young Investigator Award (2002) McKnight Technological Innovations in Neuroscience Award, McKnight Foundation (2011–2012) Gill Young Investigator Award, Gill Center for Biomolecular Science at Indiana University Bloomington (2012) Elected member, American Academy of Arts and Sciences (2019) Elected to the National Academy of Medicine (2023)

Selected publications Barak B, Zhang Z, Liu Y, Nir A, Trangle SS, Ennis M, Levandowski KM, Wang D, Quast K, Boulting GL, Li Y, Bayarsaihan D, He Z & Feng G. (2019) Neuronal deletion of Gtf2i, associated with Williams syndrome, causes behavioral and myelin alterations rescuable by a remyelinating drug. Nature Neuroscience. Mei Y, Monteiro P, Zhou Y, Kim J, Gao X, Fu Z, Feng G. (2016) Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. Nature 530: 481–484 Peça J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z, Feng G. (2012) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 472: 437–442 Welch JM, Lu J, Rodriguiz RM, Trotta NC, Peca J, Ding J-D, Feliciano C, Chen M, Adams JP, Luo J, Dudek SM, Weinberg RJ, Calakos N, Wetsel WC, Feng G. (2007) Cortico-striatal synaptic defects and OCD-like behaviors in SAPAP3 mutant mice. Nature 448: 894–900 Feng G et al. (2000) Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP. Neuron 28: 41–51