Frederick R. Maxfield

Frederick R. Maxfield is a biochemist and Vladimir Horowitz and Wanda Toscanini Horowitz Distinguished Professor in Neuroscience, Biochemistry at Weill Cornell Medical College. He received a PhD in chemistry from Cornell University and was a postdoctoral fellow at the National Cancer Institute. Before coming to Weill Cornell, he was a professor at NYU School of Medicine and Columbia University Medical Center. He is interested in the use of quantitative methods measure dynamic processes in cells. These studies have included analysis of endosome pH, kinetic mapping of endocytic pathways, and studies of cholesterol transport. Translational applications of these methods include (1) studies of the interactions of macrophages with lipoproteins and with dead cells, (2) analysis of the degradation of Alzheimer's amyloid plaque by microglia, and (3) development of novel therapies for Niemann-Pick C disease. Notable alumni from the Maxfield Lab include Peter Marks. He is one of the top highly cited researchers (h>100) according to webometrics.