Francisco Villagrán de León

José Francisco Villagrán de León (29 March 1954 – 18 May 2024) was a Guatemalan diplomat and academic.

Villagrán de León held positions as Guatemala's ambassador to the Organization of American States, the United Nations, Canada, Germany, Norway, Denmark and the United States. He was also appointed Vice-Minister of Foreign Affairs in 1986

Villagrán de León was also a founding member of the Movimiento Semilla political movement in his home country.

When Arévalo was sworn in as president in January 2024, there was speculation that Villagrán would be appointed minister of foreign affairs or ambassador to the U.S.; ultimately, however, Arévalo assigned him the position of "presidential adviser and envoy" in February 2024. Villagrán de León had been hospitalized after falling in a restaurant the previous day. President Arévalo announced the news on social media, describing his friend as "one of the most brilliant diplomats in [Guatemala's] history".