Emi K. Nishimura

Emi K. Nishimura is a Japanese biologist who is Professor of Ageing and Regeneration at the University of Tokyo. Her research considers the molecular mechanisms that underpin ageing. She was elected Fellow of the National Academy of Sciences in 2022.

Early life and education Nishimura completed her master's degree at Shiga University of Medical Science and was a doctoral researcher at Kyoto University. After earning her doctorate she moved to Harvard Medical School, where she was a postdoctoral researcher with David Fisher.

Research and career In 2009, Nishimura moved to the University of Tokyo. Nishimura studied the stem cells in hair follicles, and showed that when they are damaged by age they turn into skin, eventually causing hair follicles to shrink. The regeneration of hair follicle stem cells is a cyclical process, where they undergo active and dormant phases. These cancerous pigment stem cells can migrate out of the follicles, building melanoma on the surface of skin. Skin stem cells (keratinocyte stem cells) promote re-epithelialisation, and older stem cells are less mobile. Her work showed that in older stem cells the epidermal growth factor receptor is diminished, which results in the degradation of COL17A1. She showed that COL17A1 coordinates the movement of stem cells towards wounds. 2012 Ogawa-Seiji Award 2014 CHANEL-CE.R.I.E.S. Research Award 2017 International Federation of Pigment Cell Societies Myron Gordon Award 2022 Elected Fellow of the National Academy of Sciences

Selected publications