Ellen M. Sletten

Ellen Sletten is an American chemist who is the John McTague Career Development Chair at University of California, Los Angeles. Her research considers the use of physical organic chemistry for diagnostics and medical therapies.

Early life and education Sletten was born in New Hampshire. She earned her bachelor's degree in chemistry at Stonehill College, a liberal arts school in Easton, Massachusetts. Her undergraduate dissertation considered the stereospecific synthesis of pyrrolizidines that could be used as glycosidase inhibitors. She moved to the West Coast of the United States for her graduate studies, joining the laboratory of Carolyn R. Bertozzi at the University of California, Berkeley to work on bioorthogonal chemistry.

Research and career In 2015 Sletten was appointed to the faculty at the University of California, Los Angeles (UCLA). Her research considers the use of physical organic chemistry for diagnostics and medical therapies. At the time, short-wave infrared imaging was widely used in astronomy, but Sletten led its expansion into clinical applications. Short-wave infrared light doesn't scatter much in human tissue, and results in low tissue fluorescence compared to the near-infrared light. By combining the short-wave infrared (flavylium heterocycle-based) fluorophore with lasers and an appropriate camera, Sletten showed it was possible to capture multi-colour images of the veins and arteries of moving mice. As the imaging system could provide real-time feedback, it could be used for image-guided surgery. 2018 Thieme Chemistry Journal Award 2018 Alpha Chi Sigma Glenn T. Seaborg Award 2018 Sloan Research Fellowship 2018 NIH Director's New Innovator Award 2020 International Chemical Biology Society Young Chemical Biologist Award