Dudley Howard Williams

Dudley Howard Williams (25 May 1937 – 3 November 2010) was a British biochemist known for utilizing nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry in the study of molecular structure, especially the antibiotic vancomycin.

Biography Dudley Howard Williams was born on 25 May 1937 in Farsley, Yorkshire, the only child of Lawrence Williams, an engineers chief order clerk, and Evelyn (née Hudson). He attended Pudsey Grammar School, from where he gained a place at the University of Leeds. He graduated in 1958 with a first-class BSc in Chemistry.

In December 1962 Djerassi gave Williams three months' leave to go back to England to marry Lorna Patricia Phyllis (always known as Pat) Bedford, whom he had met at Leeds. She was a secretary in the Chemistry department. They married on 9 March 1963 and travelled to California, which they enjoyed exploring in their leisure time.

The next move was to Cambridge in 1964, to take up a junior position in Organic Chemistry, at the invitation of Lord Todd. A condition of the move was that the department should buy a Varian 100 MHz NMR spectrometer and an AEI MS9 mass spectrometer. Williams stayed at Cambridge until his retirement in 2004.

In his memoir of Dudley Williams, Sanders noted that "the different areas of [his] science overlapped, intertwined and evolved so it is not easy to separate them out for discussion".

Determining the structures and modes of action of the vancomycin family of antibiotics

Evolution

Selected publications

A full bibliography is available.

Awards and honours 1964 Fellow of Churchill College 1966 Meldola Medal, Royal Institute of Chemistry 1968 Corday–Morgan Medal, The Chemical Society 1983 Fellow of the Royal Society Tilden Medal, Royal Society of Chemistry 1984 Structural Chemistry Award, Royal Society of Chemistry 1990 Academia Europaea 1990 Bader Award, Royal Society of Chemistry 1996 Leo Friend Award, American Chemical Society

Personal life Dudley and Pat had two sons, Mark Howard in 1966 and Simon Bedford in 1968. Williams retired in 2004. Six years later he was diagnosed with an aggressive carcinoma of the liver. He died in a hospice in Cambridge on 3 November 2010.