Dario Maestrini

Dario Maestrini (23 March 1886 – 28 October 1975) was a 20th-century Italian physiologist and scientist. He was noted in the national scientific community for his research on heart, in particular for an early formulation of the Frank-Starling law, known as "Legge del cuore" or "Legge di Maestrini" by Italian doctors.

Early life Dario Maestrini was born on 23 March 1886 in Colle Umberto I, Corciano. His parents were Geremia Maestrini and Ester Monni. He was the first of three children.

At high school he focused on classical studies, and later enrolled at the University of Perugia to study veterinary medicine. During his time there he attended David Anxefeld's Institute of Physiology, and became his assistant. He graduated in 1912. After this first degree Dario Maestrini decided to enter the University of Pisa for Medicine and Surgery, where he graduated on 17 July 1914 with full marks.

Medical career On 14 November 1916 he obtained a post as lector in physiology. During the First World War he enrolled at the army as medical officer and he directed different military hospitals on the front line near the rivers Isonzo and Piave. He highlighted some chemical and functional similarities between the muscle fiber cells of the ventricle of the heart and the skeletal flexor muscles. He discovered that in the walls of the atria there were less contractile fibers than elastic and fibrous tissue. This causes this part of the heart to dilate itself more than undergo hypertrophy. Through experiments on frogs' and snails' hearts, he demonstrated the direct relationship between the volume of the blood in the heart chambers and the contractile energy. As a result of his studies he formulated his "Legge del cuore", later known as Frank-Starling law. In 1934 a new Sanatorium was inaugurated in Teramo, and Maestrini became its first director, since he had shown great skills in phthisiology during his career. This hospital, named Alessandrini-Romualdi Sanatorium after donors of funds, was the first built for the cure of tuberculosis in the entire Abruzzo

In 1963 he introduced new and more suitable branches in the electrocardiogram practice to observe the function of the right heart. He named this "right electrocardiogram".

He took part in the Medical Academy of Rome and he was president of the science section of the Science Academy of Rome. |Dario Maestrini

Three years later, in 1918, Ernest Starling came to the same conclusions, publishing in London "The law of the heart". The publication was based on Maestrini's 1915 article L'influenza del peso sulla corrente d'azione e sul lavoro meccanico del muscolo cardiaco in Archivio di Farmacologia e Scienze Affini. The law became known as the Frank-Starling law after Starling, well-known internationally, and Otto Frank, although in Italy it was called "Maestrini-Starling law". A brief note with title "The law of the heart" by Maestrini's adopted son, Fulvio Pezza, head of oncology in Novara, stating that Maestrini was the originator of the law as Starling himself had said, was published in The Lancet on 23 November 1974.

In the last months of his life Maestrini had the satisfaction of his priority being recognized, with the name "Maestrini-Starling Law" being proposed in The Lancet.

Personal life During his stay on the front line near the river Isonzo as an Italian soldier, Dario Maestrini met Giuseppina Bauzon, a woman of the small town of Romans d'Isonzo. After the end of the war they married and had a daughter, Anna Maria, who died at the age of 21.

Political engagement Maestrini was involved in the anti-fascist movement. In 1943 he entered the National Liberation Committee (CLN) and he was part of "Pio Borri" brigade. He became Health and Hygiene Alderman of the municipality of Arezzo in the first junta made up after the liberation on behalf of Action Party, and in 1948 he was awarded the title of Patriot.

Main writings L’influenza del peso sulla corrente d’azione e sul lavoro meccanico del muscolo cardiaco, Archivio di Farmacologia e Scienze Affini, XX, 1915 Cardiografia ed elettrocardiografia:angiografia, Il Policlinico, Luigi Pozzi editore, Roma 1923 Nuove vedute e nuove realtà in Cardiologia 1911-1967, Luigi Pozzi editore, Roma 1967