Daniele Manfredini

Daniele Manfredini is an Italian dentist and academic. He is a professor of Dentistry and the director of the Orofacial Pain Unit at the University of Siena.

Manfredini's research has centered on temporomandibular disorders (TMDs) and bruxism.

Education Manfredini received his Degree in Dentistry and Dental Prosthetics (D.D.S) along with his Master of Science in Occlusion and Craniomandibular Disorders from the University of Pisa in 1999 and 2001, respectively. Following this, he received a Ph.D. in Dentistry from the Academic Centre for Dentistry Amsterdam (ACTA) in 2011. He received a Post-Graduate Specialty in Orthodontics from the University of Ferrara in 2017 and obtained Diplomate Status from the American Board of Orofacial Pain in 2021.

Career Manfredini began his academic career in 2006 as an assistant professor and coordinator of research projects at the TMD clinic at the University of Padua, roles he held until 2016. In 2017, the Italian Ministry of University and Research (MIUR) appointed him to the rank of full professor. and vice president of the International Association for Orofacial Pain (IAOFP). He is the founder of the Italian Society of Prosthodontics and Oral Rehabilitation (SIPRO). He is the editor-in-chief of Cranio: The Journal of Craniomandibular & Sleep Practice and the coordinator of the reference document on Temporomandibular Disorders standard of care on behalf of the International Association for Dental Research (IADR). Additionally, for IADR, he was President of the International Board for the Bruxism Consensus Panel.

Research Manfredini has authored 360 peer-reviewed journal publications. His research is based on TMDs, bruxism, and orofacial pain, focusing on their etiology, diagnosis, and clinical management. Through clinical research and systematic reviews, he has examined the multifactorial nature of bruxism and highlighted the interactions among biological, psychological, and behavioral factors associated with it. He has also addressed sleep and awake bruxism. Moreover, he has contributed to international efforts to refine the conceptual definition of bruxism and improve its assessment in clinical and research contexts.

Manfredini has studied diagnostic approaches for TMDs, emphasizing the assessment of psychosocial factors such as depression and somatization. He also examined the therapeutic approaches for TMDs with an emphasis on the dismantling of old dogmas centered around the correction of dental occlusion. Additionally, he has examined conservative management strategies, including occlusal splints for TMDs, behavioral interventions for bruxism management, and oral appliances for sleep bruxism. His publications have analyzed the relationship between bruxism and TMDs. He has also contributed to the development of the STAB (Standardized Tool for the Assessment of Bruxism), which is a framework that integrates information related to etiology and clinical consequences.

Selected articles