Cleopatra of Macedon
4th-century BC Macedonian princess and queen regent of Epirus
About Cleopatra of Macedon
Lived 350 BC – 308 BC (aged 41–42). Cleopatra of Macedon was a politician and queen regnant.
Cleopatra of Macedonia (Greek: Κλεοπάτρα της Μακεδονίας; 355/354 BC – 308 BC), or Cleopatra of Epirus (Greek: Κλεοπάτρα της Ηπείρου) was an ancient Macedonian princess and later queen regent of Epirus. The daughter of Philip II of Macedon and Olympias of Epirus, she was the only full sibling of Alexander the Great. Her other siblings include half sisters Thessalonike and Cynane, and half-brother Philip III of Macedon.
Early life Cleopatra grew up in the care of her mother in Pella. Cleopatra, Olympias, Leonidas, and Alexander's friends were Alexander's closest relationships until Alexander was sent to Mieza at 13. In 338 BC, Cleopatra stayed in Pella with her father while her mother Olympias fled to exile in Epirus with her Molossian brother Alexander I of Epirus (Cleopatra's uncle), and Cleopatra's brother Alexander fled to Illyria. Soon Philip felt he had to ally himself to Alexander I by offering his daughter's hand in marriage.
Rule in Epirus Immediately after her father's murder, Cleopatra and her husband-uncle Alexander went from Macedon back to Epirus. It is believed that the couple had two children, Neoptolemus II of Epirus and Cadmeia (named for her brother's defeat of the Theban revolt which began by attacking the garrison on the Cadmea).
Cleopatra held her brother Alexander's official favor, and likely kept in close contact with him while he was on his conquest to the east. Alexander considered her and Olympias as the inner circle of his basileia. ("welcomers of sacred ambassadors"), in the recently established Epirote alliance. Cleopatra was significantly the only woman on the list. Her position as official welcomer would have allowed her to keep a finger on whatever was happening anywhere in Greece. Cleopatra may also have been instrumental in implementing her brother's policies regarding grain shipments. with a handsome young man.
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Important facts
People in Cleopatra of Macedon's life
Named in this biography and alive at the same time
Contemporaries
People whose lives overlapped Cleopatra of Macedon's
Frequently asked questions
Who was Cleopatra of Macedon?
4th-century BC Macedonian princess and queen regent of Epirus
When was Cleopatra of Macedon born?
Cleopatra of Macedon was born in 350 BC.
When did Cleopatra of Macedon die?
Cleopatra of Macedon died in 308 BC in Sardis.
What was Cleopatra of Macedon's occupation?
Cleopatra of Macedon was a politician and queen regnant.
What nationality was Cleopatra of Macedon?
Cleopatra of Macedon's recorded nationality: Macedonia.
Sources & further reading
· Wikipedia: Cleopatra of Macedon
· DBpedia: Cleopatra of Macedon
Cite this page
APA: Biography.guide. (2026). Cleopatra of Macedon. https://biography.guide/cleopatra-of-macedon/
MLA: "Cleopatra of Macedon." Biography.guide, https://biography.guide/cleopatra-of-macedon/.
Chicago: "Cleopatra of Macedon." Biography.guide. https://biography.guide/cleopatra-of-macedon/.
Data last updated: 2026-09-20 · Spot an error? Report a correction.
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