Christoph W Michalski

Christoph Michalski (born 1977) is a German surgeon. He is Director of the Department of General, Abdominal, and Transplant Surgery at Heidelberg University Hospital. He is a full Professor of Surgery and Chair of General Surgery at Heidelberg University.

There, he worked as a staff surgeon before becoming attending surgeon. He was promoted to assistant professor at Heidelberg University Hospital.

Research As a surgeon, Michalski specializes primarily in complex tumour surgery, transplant surgery, and modern minimally invasive procedures, such as robot-assisted surgery. His research focuses particularly on pancreatic carcinogenesis, pancreatic carcinoma, and surgical oncology, as well as digital applications in surgery. Additionally, he conducts clinical studies on surgery and multimodality therapy of gastrointestinal tumour diseases.

Publications (selection)

Kong, B., Cheng, T., Qian, C., Michalski, C. W. et al. (2015). Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma. Molecular Cancer, 14, 212. doi:10.1186/s12943-015-0483-1. . Kong, B., Wu, W., Cheng, T., Michalski, C. W. et al. (2016). A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling. Gut, 65(4), 647–657. doi:10.1136/gutjnl-2014-307616. . Heckler, M., Michalski, C. W., Schaefle, S., Kaiser, J., Büchler, M. W., & Hackert, T. (2017). The Sendai and Fukuoka consensus criteria for the management of branch duct IPMN — A meta-analysis on their accuracy. Pancreatology: official journal of the International Association of Pancreatology (IAP) ... [et al.], 17(2), 255–262. doi:10.1016/j.pan.2017.01.011. . Kong, B., Bruns, P., Behler, N. A., Michalski, C. W. et al.(2018). Dynamic landscape of pancreatic carcinogenesis reveals early molecular networks of malignancy. Gut, 67(1), 146–156. doi:10.1136/gutjnl-2015-310913. . Cheng, T., Zhang, Z., Jian, Z., Raulefs, S., Schlitter, A. M., Steiger, K., Maeritz, N., Zhao, Y., Shen, S., Zou, X., Ceyhan, G. O., Friess, H., Kleeff, J., Michalski, C. W., & Kong, B. (2019). Ductal obstruction promotes formation of preneoplastic lesions from the pancreatic ductal compartment. International Journal of Cancer, 144(10), 2529–2538. doi:10.1002/ijc.31981. . Tanaka, M., Heckler, M., Liu, B., Heger, U., Hackert, T., & Michalski, C. W. (2019). Cytologic Analysis of Pancreatic Juice Increases Specificity of Detection of Malignant IPMN-A Systematic Review. Clinical Hastroenterology and Hepatology: the official clinical practice journal of the American Gastroenterological Association, 17(11), 2199–2211.e21. doi:10.1016/j.cgh.2018.12.034. . Zhang, Z., Li, H., Deng, Y., Kong, B. & Michalski, C. W. et al. (2021). AGR2-Dependent Nuclear Import of RNA Polymerase II Constitutes a Specific Target of Pancreatic Ductal Adenocarcinoma in the Context of Wild-Type p53. Gastroenterology, 161(5), 1601–1614.e23. doi:10.1053/j.gastro.2021.07.030. .