Caterina Cybo

Caterina Cybo (13 September 1501 – 17 February 1557) was an Italian ruler. She was the daughter of Maddalena de Medici and Franceschetto Cybo. She was regent of the Duchy of Camerino between 1527 and 1535 during the minority of her daughter Giulia da Varano. She was a follower of the Italian religious reformist movement of the 16th century.

She was born in Ponzano, and was a granddaughter of the more famous Lorenzo de Medici.

In 1527 her husband, Duke Giovanni Maria of Camerino, died from the plague. After his death, Caterina forcefully ensured that she remained in control of the duchy, and that her daughter would inherit.