Barry Gusterson

fields = Pathology, Cancer workplaces = Plainlist| Institute of Cancer Research University of Glasgow (re-named the Toby Robins Breast Cancer Now Research Centre). In 2000-2010 he was Professor of Pathology in Glasgow and was the project lead responsible for building the Wolfson Wohl Cancer Centre. He initiated the concept to build the first dedicated breast cancer research centre and was appointed Founding Director of the Toby Robins, Breakthrough Breast Cancer Research Centre in 1998. In 2000 he moved to Glasgow University, where he held a number of positions as Professor of Pathology, and Head of Forensic Science and Medicine, which won an £18.5 M contract from the Crown Office in 2006. Alongside this, he initiated and was Director of the Glasgow Biobank. The two cancer centres initiated by Gusterson were both developed as major fund-raising projects, in which he played a key role as the clinical lead. Gusterson retired in 2011 and became a Director of Moorfield’s Eye Charity and a member of Council for St George's, University of London.

Research Human Squamous Cell Carcinomas and Skin

Gusterson has 324 cited publications in Semantic Scholar and 302 in Research Gate

Gusterson’s early work focused on in vitro studies of differentiation of human oral mucosa, skin and squamous cell carcinomas of the head and neck. This led to the demonstration of the normal human tissue distribution and overexpression and amplification of the Epidermal Growth Factor Receptors (EGFR) as a feature of squamous cell carcinomas. Later studies with Tim Crook and others demonstrated the high expression of p53 in head and neck cancer and mutations in BRCA1 and BRCA2 breast cancers.

The differentiated normal skin in vitro was used for human skin grafts in burns patients.

Breast Cancer and Normal Breast Development

Work was mainly based on clinico-pathological studies of human breast cancer and normal breast development. Working as Director of Pathology for the International Breast Cancer Study Group (IBCSG) a BioBank was established for international clinical trials and a Translational Research Working Group to assess research proposals which Gusterson chaired. This collaboration resulted in numerous publications, including the demonstration of c-erbB-2 (HER2) overexpression as a prognostic indicator in breast cancer Interpretation of the molecular classifications of breast cancer in the context of the normal lineages in the breast gave insights into the limitations of these new technologies. Work on human breast development described the cell types involved in differentiation of the human breast and their biological significance. Gusterson is also known as an expert in the pathology of animal models of human breast cancer and studies on the biology of involution. With Beatrice Howard the locus was defined for breast development in the mouse mammary gland.

Human Sarcomas

Collaborations with Janet Shipley and Colin Cooper resulted in the identification of translocations and genes in a number of soft tissue sarcomas.