Ashikaga Mitsukane

(1378–1409) was a Nanboku-chō period warrior, and the Kamakura-fu's third Kantō kubō, (Shōgun Deputy). Being the eldest son, he succeeded his father Ujimitsu in 1398 at the age of 21 when he died during an epidemic. This because he realized the importance of the area to control the whole Kantō region. This increased immensely the support given by the Yūki Shirakawa family to his brothers, and therefore to himself. The plan however failed because Ōuchi was immediately defeated.

Date Masamune, ancestor of the more famous Tokugawa tozama, together with some allies had rebelled in Southern and Middle Mutsu against Kamakura, so in 1402 Mitsukane sent Uesugi Ujinori (the future Uesugi Zenshū) to quell the revolt. Whether the rumor had any basis is unclear but, in that case, it may well have been a consequence of his lack of success in defeating the shogunate. He died of natural causes at the age of 32. As his predecessors, he was buried at Kamakura's Zuisen-ji.